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Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domain
Human transmembrane adenylyl cyclase 9 (AC9) is not regulated by heterotrimeric G proteins. Key to the resistance to stimulation by Gs-coupled receptors (GsRs) is auto-inhibition by the COOH-terminal domain (C2b). The present study investigated the role of the C2b domain in the regulation of cyclic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Life Science Alliance LLC
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873982/ https://www.ncbi.nlm.nih.gov/pubmed/36657828 http://dx.doi.org/10.26508/lsa.202201791 |