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Governing biotechnology to provide safety and security and address ethical, legal, and social implications

The field of biotechnology has produced a wide variety of materials and products which are rapidly entering the commercial marketplace. While many developments promise revolutionary benefits, some of them pose uncertain or largely untested risks and may spur debate, consternation, and outrage from i...

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Autores principales: Trump, Benjamin, Cummings, Christopher, Klasa, Kasia, Galaitsi, Stephanie, Linkov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873990/
https://www.ncbi.nlm.nih.gov/pubmed/36712887
http://dx.doi.org/10.3389/fgene.2022.1052371
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author Trump, Benjamin
Cummings, Christopher
Klasa, Kasia
Galaitsi, Stephanie
Linkov, Igor
author_facet Trump, Benjamin
Cummings, Christopher
Klasa, Kasia
Galaitsi, Stephanie
Linkov, Igor
author_sort Trump, Benjamin
collection PubMed
description The field of biotechnology has produced a wide variety of materials and products which are rapidly entering the commercial marketplace. While many developments promise revolutionary benefits, some of them pose uncertain or largely untested risks and may spur debate, consternation, and outrage from individuals and groups who may be affected by their development and use. In this paper we show that the success of any advanced genetic development and usage requires that the creators establish technical soundness, ensure safety and security, and transparently represent the product’s ethical, legal, and social implications (ELSI). We further identify how failures to address ELSI can manifest as significant roadblocks to product acceptance and adoption and advocate for use of the “safety-by-design” governance philosophy. This approach requires addressing risk and ELSI needs early and often in the technology development process to support innovation while providing security and safety for workers, the public, and the broader environment. This paper identifies and evaluates major ELSI challenges and perspectives to suggest a methodology for implementing safety-by-design in a manner consistent with local institutions and politics. We anticipate the need for safety-by-design approach to grow and permeate biotechnology governance structures as the field expands in scientific and technological complexity, increases in public attention and prominence, and further impacts human health and the environment.
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spelling pubmed-98739902023-01-26 Governing biotechnology to provide safety and security and address ethical, legal, and social implications Trump, Benjamin Cummings, Christopher Klasa, Kasia Galaitsi, Stephanie Linkov, Igor Front Genet Genetics The field of biotechnology has produced a wide variety of materials and products which are rapidly entering the commercial marketplace. While many developments promise revolutionary benefits, some of them pose uncertain or largely untested risks and may spur debate, consternation, and outrage from individuals and groups who may be affected by their development and use. In this paper we show that the success of any advanced genetic development and usage requires that the creators establish technical soundness, ensure safety and security, and transparently represent the product’s ethical, legal, and social implications (ELSI). We further identify how failures to address ELSI can manifest as significant roadblocks to product acceptance and adoption and advocate for use of the “safety-by-design” governance philosophy. This approach requires addressing risk and ELSI needs early and often in the technology development process to support innovation while providing security and safety for workers, the public, and the broader environment. This paper identifies and evaluates major ELSI challenges and perspectives to suggest a methodology for implementing safety-by-design in a manner consistent with local institutions and politics. We anticipate the need for safety-by-design approach to grow and permeate biotechnology governance structures as the field expands in scientific and technological complexity, increases in public attention and prominence, and further impacts human health and the environment. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9873990/ /pubmed/36712887 http://dx.doi.org/10.3389/fgene.2022.1052371 Text en Copyright © 2023 Trump, Cummings, Klasa, Galaitsi and Linkov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Trump, Benjamin
Cummings, Christopher
Klasa, Kasia
Galaitsi, Stephanie
Linkov, Igor
Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title_full Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title_fullStr Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title_full_unstemmed Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title_short Governing biotechnology to provide safety and security and address ethical, legal, and social implications
title_sort governing biotechnology to provide safety and security and address ethical, legal, and social implications
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873990/
https://www.ncbi.nlm.nih.gov/pubmed/36712887
http://dx.doi.org/10.3389/fgene.2022.1052371
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