Disulfide-containing polymer delivery of C527 and a Platinum(IV) prodrug selectively inhibited protein ubiquitination and tumor growth on cisplatin resistant and patient-derived liver cancer models

USP1 (Ubiquitin-specific protease 1) is closely related to the prognosis of patients with liver cancer and plays an important role in DNA damage repair. C527 is a selective USP1 inhibitor (USP1i), which can regulate the protein ubiquitination to effectively inhibit the proliferation of cancer cells....

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Detalles Bibliográficos
Autores principales: Shang, Kun, Zhang, Lingpu, Yu, Yingjie, Xiao, Haihua, Gao, Yajuan, Yang, Liu, Huang, Jia, Song, Haiqin, Han, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Early Career Board Member article collection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874064/
https://www.ncbi.nlm.nih.gov/pubmed/36713799
http://dx.doi.org/10.1016/j.mtbio.2023.100548

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