Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization

INTRODUCTION: Oligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identified till now. A large number of OAT-affected cases remain largely unknown. METHODS: Here, Whole-exome sequencing (WES) in 725 idiopathic OAT patients...

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Detalles Bibliográficos
Autores principales: Bai, Haowei, Sha, Yanwei, Tan, Yueqiu, Li, Peng, Zhang, Yuxiang, Xu, Junwei, Xu, Shuai, Ji, Zhiyong, Wang, Xiaobo, Chen, Wei, Zhang, Jianxiong, Yao, Chencheng, Li, Zheng, Zhi, Erlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874084/
https://www.ncbi.nlm.nih.gov/pubmed/36714566
http://dx.doi.org/10.3389/fendo.2022.1099270

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