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CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas

BACKGROUND: Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifi...

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Autores principales: Tian, Guopeng, Li, Qiao, Niu, Liang, Luo, Yusong, Wang, Hongyu, Kang, Wei, Fang, Xiang, Bai, Shengwei, Yuan, Guoqiang, Pan, Yawen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874090/
https://www.ncbi.nlm.nih.gov/pubmed/36713560
http://dx.doi.org/10.3389/fonc.2022.1025065
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author Tian, Guopeng
Li, Qiao
Niu, Liang
Luo, Yusong
Wang, Hongyu
Kang, Wei
Fang, Xiang
Bai, Shengwei
Yuan, Guoqiang
Pan, Yawen
author_facet Tian, Guopeng
Li, Qiao
Niu, Liang
Luo, Yusong
Wang, Hongyu
Kang, Wei
Fang, Xiang
Bai, Shengwei
Yuan, Guoqiang
Pan, Yawen
author_sort Tian, Guopeng
collection PubMed
description BACKGROUND: Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of programmed lytic death that has been recently discovered. Caspase 4 (CASP4) plays a key role in pyroptosis. Many studies have shown that pyroptosis is not only related to inflflammation but is also closely related to the occurrence and development of most tumors. This study aimed to prove that CASP4 has a key role in the mechanism of gliomas. METHODS: We used expression data from The Cancer Genome Atlas and the Chinese Glioma Genome Atlas to explore the relationship between CASP4 expression and glioma prognosis. The differential expression of CASP4 in gliomas and normal tissues was fifirst tested, and then the connection between CASP4 and tumor prognosis was explored. The relationship between CASP4 expression and immune cell infifiltration was also investigated. Finally, the possible pathways were analyzed using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis. RESULTS: CASP4 was highly expressed and associated with a signifificantly lower survival rate in patients with glioma. It could also inflfluence immune cell infifiltration by releasing cytokines. CONCLUSION: CASP4 can be a diagnostic biomarker and is a promising therapeutic target for gliomas.
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spelling pubmed-98740902023-01-26 CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas Tian, Guopeng Li, Qiao Niu, Liang Luo, Yusong Wang, Hongyu Kang, Wei Fang, Xiang Bai, Shengwei Yuan, Guoqiang Pan, Yawen Front Oncol Oncology BACKGROUND: Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of programmed lytic death that has been recently discovered. Caspase 4 (CASP4) plays a key role in pyroptosis. Many studies have shown that pyroptosis is not only related to inflflammation but is also closely related to the occurrence and development of most tumors. This study aimed to prove that CASP4 has a key role in the mechanism of gliomas. METHODS: We used expression data from The Cancer Genome Atlas and the Chinese Glioma Genome Atlas to explore the relationship between CASP4 expression and glioma prognosis. The differential expression of CASP4 in gliomas and normal tissues was fifirst tested, and then the connection between CASP4 and tumor prognosis was explored. The relationship between CASP4 expression and immune cell infifiltration was also investigated. Finally, the possible pathways were analyzed using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis. RESULTS: CASP4 was highly expressed and associated with a signifificantly lower survival rate in patients with glioma. It could also inflfluence immune cell infifiltration by releasing cytokines. CONCLUSION: CASP4 can be a diagnostic biomarker and is a promising therapeutic target for gliomas. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874090/ /pubmed/36713560 http://dx.doi.org/10.3389/fonc.2022.1025065 Text en Copyright © 2023 Tian, Li, Niu, Luo, Wang, Kang, Fang, Bai, Yuan and Pan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tian, Guopeng
Li, Qiao
Niu, Liang
Luo, Yusong
Wang, Hongyu
Kang, Wei
Fang, Xiang
Bai, Shengwei
Yuan, Guoqiang
Pan, Yawen
CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title_full CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title_fullStr CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title_full_unstemmed CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title_short CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
title_sort casp4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874090/
https://www.ncbi.nlm.nih.gov/pubmed/36713560
http://dx.doi.org/10.3389/fonc.2022.1025065
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