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An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies h...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874101/ https://www.ncbi.nlm.nih.gov/pubmed/36714578 http://dx.doi.org/10.3389/fendo.2022.1065263 |
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author | Liu, Xiaomeng Zhang, Zhi Song, Yajie Xie, Hengchang Dong, Meng |
author_facet | Liu, Xiaomeng Zhang, Zhi Song, Yajie Xie, Hengchang Dong, Meng |
author_sort | Liu, Xiaomeng |
collection | PubMed |
description | Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity. |
format | Online Article Text |
id | pubmed-9874101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98741012023-01-26 An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications Liu, Xiaomeng Zhang, Zhi Song, Yajie Xie, Hengchang Dong, Meng Front Endocrinol (Lausanne) Endocrinology Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874101/ /pubmed/36714578 http://dx.doi.org/10.3389/fendo.2022.1065263 Text en Copyright © 2023 Liu, Zhang, Song, Xie and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Liu, Xiaomeng Zhang, Zhi Song, Yajie Xie, Hengchang Dong, Meng An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title | An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title_full | An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title_fullStr | An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title_full_unstemmed | An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title_short | An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications |
title_sort | update on brown adipose tissue and obesity intervention: function, regulation and therapeutic implications |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874101/ https://www.ncbi.nlm.nih.gov/pubmed/36714578 http://dx.doi.org/10.3389/fendo.2022.1065263 |
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