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An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies h...

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Autores principales: Liu, Xiaomeng, Zhang, Zhi, Song, Yajie, Xie, Hengchang, Dong, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874101/
https://www.ncbi.nlm.nih.gov/pubmed/36714578
http://dx.doi.org/10.3389/fendo.2022.1065263
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author Liu, Xiaomeng
Zhang, Zhi
Song, Yajie
Xie, Hengchang
Dong, Meng
author_facet Liu, Xiaomeng
Zhang, Zhi
Song, Yajie
Xie, Hengchang
Dong, Meng
author_sort Liu, Xiaomeng
collection PubMed
description Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity.
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spelling pubmed-98741012023-01-26 An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications Liu, Xiaomeng Zhang, Zhi Song, Yajie Xie, Hengchang Dong, Meng Front Endocrinol (Lausanne) Endocrinology Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874101/ /pubmed/36714578 http://dx.doi.org/10.3389/fendo.2022.1065263 Text en Copyright © 2023 Liu, Zhang, Song, Xie and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Xiaomeng
Zhang, Zhi
Song, Yajie
Xie, Hengchang
Dong, Meng
An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title_full An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title_fullStr An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title_full_unstemmed An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title_short An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
title_sort update on brown adipose tissue and obesity intervention: function, regulation and therapeutic implications
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874101/
https://www.ncbi.nlm.nih.gov/pubmed/36714578
http://dx.doi.org/10.3389/fendo.2022.1065263
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