Cargando…
(Thyroid) Hormonal regulation of breast cancer cells
Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 (‘thyrointegrin’) to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive breast cancer cells, T4 via the integrin promotes ERα-dep...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874134/ https://www.ncbi.nlm.nih.gov/pubmed/36714596 http://dx.doi.org/10.3389/fendo.2022.1109555 |
_version_ | 1784877738431086592 |
---|---|
author | Hercbergs, Aleck Lin, Hung-Yun Mousa, Shaker A. Davis, Paul J. |
author_facet | Hercbergs, Aleck Lin, Hung-Yun Mousa, Shaker A. Davis, Paul J. |
author_sort | Hercbergs, Aleck |
collection | PubMed |
description | Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 (‘thyrointegrin’) to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive breast cancer cells, T4 via the integrin promotes ERα-dependent cancer growth in the absence of estrogen. Thus, tumor growth in the post-menopausal patient with ERα-positive cancer may again be ER-dependent because of T4. Additional mechanisms by which T4 may contribute uniquely to aggressive breast cancer behavior—independently of ER—are stimulation of immune checkpoint inhibitor gene expression and of several anti-apoptosis mechanisms. These observations may call for consideration of elimination of host T4 production in breast cancer patients whose response is suboptimal to standard chemotherapy regimens. Euthyroidism in such a setting may be maintained with exogenous 3,3’,5-triiodo-L-thyronine (T3). |
format | Online Article Text |
id | pubmed-9874134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98741342023-01-26 (Thyroid) Hormonal regulation of breast cancer cells Hercbergs, Aleck Lin, Hung-Yun Mousa, Shaker A. Davis, Paul J. Front Endocrinol (Lausanne) Endocrinology Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 (‘thyrointegrin’) to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive breast cancer cells, T4 via the integrin promotes ERα-dependent cancer growth in the absence of estrogen. Thus, tumor growth in the post-menopausal patient with ERα-positive cancer may again be ER-dependent because of T4. Additional mechanisms by which T4 may contribute uniquely to aggressive breast cancer behavior—independently of ER—are stimulation of immune checkpoint inhibitor gene expression and of several anti-apoptosis mechanisms. These observations may call for consideration of elimination of host T4 production in breast cancer patients whose response is suboptimal to standard chemotherapy regimens. Euthyroidism in such a setting may be maintained with exogenous 3,3’,5-triiodo-L-thyronine (T3). Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874134/ /pubmed/36714596 http://dx.doi.org/10.3389/fendo.2022.1109555 Text en Copyright © 2023 Hercbergs, Lin, Mousa and Davis https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Hercbergs, Aleck Lin, Hung-Yun Mousa, Shaker A. Davis, Paul J. (Thyroid) Hormonal regulation of breast cancer cells |
title | (Thyroid) Hormonal regulation of breast cancer cells |
title_full | (Thyroid) Hormonal regulation of breast cancer cells |
title_fullStr | (Thyroid) Hormonal regulation of breast cancer cells |
title_full_unstemmed | (Thyroid) Hormonal regulation of breast cancer cells |
title_short | (Thyroid) Hormonal regulation of breast cancer cells |
title_sort | (thyroid) hormonal regulation of breast cancer cells |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874134/ https://www.ncbi.nlm.nih.gov/pubmed/36714596 http://dx.doi.org/10.3389/fendo.2022.1109555 |
work_keys_str_mv | AT hercbergsaleck thyroidhormonalregulationofbreastcancercells AT linhungyun thyroidhormonalregulationofbreastcancercells AT mousashakera thyroidhormonalregulationofbreastcancercells AT davispaulj thyroidhormonalregulationofbreastcancercells |