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CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis
INTRODUCTION: To explore the CT characteristics for the prediction of long term survival in gastric cancer patients with synchronous peritoneal metastasis (PM). MATERIALS AND METHODS: Sixty-six patients diagnosed as gastric cancer with synchronous peritoneum metastasis were enrolled in this retrospe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874217/ https://www.ncbi.nlm.nih.gov/pubmed/36713539 http://dx.doi.org/10.3389/fonc.2022.1061806 |
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author | Li, Jiazheng Cong, Lin Sun, Xuefeng Li, Xiaoting Chen, Yang Cai, Jieyuan He, Meng Zhang, Xiaotian Tang, Lei |
author_facet | Li, Jiazheng Cong, Lin Sun, Xuefeng Li, Xiaoting Chen, Yang Cai, Jieyuan He, Meng Zhang, Xiaotian Tang, Lei |
author_sort | Li, Jiazheng |
collection | PubMed |
description | INTRODUCTION: To explore the CT characteristics for the prediction of long term survival in gastric cancer patients with synchronous peritoneal metastasis (PM). MATERIALS AND METHODS: Sixty-six patients diagnosed as gastric cancer with synchronous peritoneum metastasis were enrolled in this retrospective study. Ten anatomic peritoneal regions were evaluated to check for the signs of PM on CT. One positive area equaled one score. The CT characteristic-based PM score (CT-PMS) was the sum of the total points assigned to all 10 regions, with a range of 0–10. The triple tract dilatation (TTD) sign caused by peritoneal metastasis, the presence of extensive lymph node metastasis (ELM), and the grade of ascites were recorded. The overall survival (OS) was used as the prognostic indicator. The performance of the CT characteristics was assessed by the Kaplan–Meier analysis and Cox proportional hazards model, while its reproducibility was evaluated by Kappa statistic and weighted Kappa statistic. RESULTS: Patients with a CT-PMS of 3–10 had significantly poorer OS (P = .02). Patients with either the presence of TTD sign, or ELM had a trend toward unfavorable OS (both P = .07), and when CT-PMS of 3–10 was detected simultaneously, the survival was further reduced (P = .00 for TTD sign; P = .01 for ELM). The grade of ascites failed to show a significant correlation with OS. The interobserver reproducibility for assessing the CT-PMS, the presence of TTD sign, the presence of ELM, and the grade of ascites had a substantial to almost perfect agreement. CONCLUSION: The prognosis of gastric cancer patients with PM has a correlation with the extent of metastasis dissemination on baseline CT. A CT-PMS of 3–10 is associated with a worse prognosis than that of 0–2. The presence of TTD sign and ELM may help further select patients with extraordinarily poor prognoses. |
format | Online Article Text |
id | pubmed-9874217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98742172023-01-26 CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis Li, Jiazheng Cong, Lin Sun, Xuefeng Li, Xiaoting Chen, Yang Cai, Jieyuan He, Meng Zhang, Xiaotian Tang, Lei Front Oncol Oncology INTRODUCTION: To explore the CT characteristics for the prediction of long term survival in gastric cancer patients with synchronous peritoneal metastasis (PM). MATERIALS AND METHODS: Sixty-six patients diagnosed as gastric cancer with synchronous peritoneum metastasis were enrolled in this retrospective study. Ten anatomic peritoneal regions were evaluated to check for the signs of PM on CT. One positive area equaled one score. The CT characteristic-based PM score (CT-PMS) was the sum of the total points assigned to all 10 regions, with a range of 0–10. The triple tract dilatation (TTD) sign caused by peritoneal metastasis, the presence of extensive lymph node metastasis (ELM), and the grade of ascites were recorded. The overall survival (OS) was used as the prognostic indicator. The performance of the CT characteristics was assessed by the Kaplan–Meier analysis and Cox proportional hazards model, while its reproducibility was evaluated by Kappa statistic and weighted Kappa statistic. RESULTS: Patients with a CT-PMS of 3–10 had significantly poorer OS (P = .02). Patients with either the presence of TTD sign, or ELM had a trend toward unfavorable OS (both P = .07), and when CT-PMS of 3–10 was detected simultaneously, the survival was further reduced (P = .00 for TTD sign; P = .01 for ELM). The grade of ascites failed to show a significant correlation with OS. The interobserver reproducibility for assessing the CT-PMS, the presence of TTD sign, the presence of ELM, and the grade of ascites had a substantial to almost perfect agreement. CONCLUSION: The prognosis of gastric cancer patients with PM has a correlation with the extent of metastasis dissemination on baseline CT. A CT-PMS of 3–10 is associated with a worse prognosis than that of 0–2. The presence of TTD sign and ELM may help further select patients with extraordinarily poor prognoses. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874217/ /pubmed/36713539 http://dx.doi.org/10.3389/fonc.2022.1061806 Text en Copyright © 2023 Li, Cong, Sun, Li, Chen, Cai, He, Zhang and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Jiazheng Cong, Lin Sun, Xuefeng Li, Xiaoting Chen, Yang Cai, Jieyuan He, Meng Zhang, Xiaotian Tang, Lei CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title | CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title_full | CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title_fullStr | CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title_full_unstemmed | CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title_short | CT characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
title_sort | ct characteristics for predicting prognosis of gastric cancer with synchronous peritoneal metastasis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874217/ https://www.ncbi.nlm.nih.gov/pubmed/36713539 http://dx.doi.org/10.3389/fonc.2022.1061806 |
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