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A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. This study in...

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Detalles Bibliográficos
Autores principales:	Sato, Kakeru, Seki, Tatsuya, Mizutani, Asuka, Muranaka, Yuka, Hirota, Shiho, Nishi, Kodai, Yamazaki, Kana, Nishii, Ryuichi, Nakanishi, Takeo, Tamai, Ikumi, Kawai, Keiichi, Kobayashi, Masato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874220/ https://www.ncbi.nlm.nih.gov/pubmed/36712667 http://dx.doi.org/10.3389/fphar.2022.1069321

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