Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics

Gene expression in mammalian cells is highly variable and episodic, resulting in a series of discontinuous bursts of mRNAs. A challenge is to understand how static promoter architecture and dynamic feedback regulations dictate bursting on a genome-wide scale. Although single-cell RNA sequencing (scR...

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Detalles Bibliográficos
Autores principales: Luo, Songhao, Wang, Zihao, Zhang, Zhenquan, Zhou, Tianshou, Zhang, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874261/
https://www.ncbi.nlm.nih.gov/pubmed/36583343
http://dx.doi.org/10.1093/nar/gkac1204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874261/
https://www.ncbi.nlm.nih.gov/pubmed/36583343
http://dx.doi.org/10.1093/nar/gkac1204

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