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Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics
Gene expression in mammalian cells is highly variable and episodic, resulting in a series of discontinuous bursts of mRNAs. A challenge is to understand how static promoter architecture and dynamic feedback regulations dictate bursting on a genome-wide scale. Although single-cell RNA sequencing (scR...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874261/ https://www.ncbi.nlm.nih.gov/pubmed/36583343 http://dx.doi.org/10.1093/nar/gkac1204 |