The role of Hippo pathway in ferroptosis

The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, prolifera...

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Detalles Bibliográficos
Autores principales: Xiang, Jiangxia, Jiang, Mengmeng, Du, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874674/
https://www.ncbi.nlm.nih.gov/pubmed/36713588
http://dx.doi.org/10.3389/fonc.2022.1107505
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author Xiang, Jiangxia
Jiang, Mengmeng
Du, Xing
author_facet Xiang, Jiangxia
Jiang, Mengmeng
Du, Xing
author_sort Xiang, Jiangxia
collection PubMed
description The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.
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spelling pubmed-98746742023-01-26 The role of Hippo pathway in ferroptosis Xiang, Jiangxia Jiang, Mengmeng Du, Xing Front Oncol Oncology The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874674/ /pubmed/36713588 http://dx.doi.org/10.3389/fonc.2022.1107505 Text en Copyright © 2023 Xiang, Jiang and Du https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xiang, Jiangxia
Jiang, Mengmeng
Du, Xing
The role of Hippo pathway in ferroptosis
title The role of Hippo pathway in ferroptosis
title_full The role of Hippo pathway in ferroptosis
title_fullStr The role of Hippo pathway in ferroptosis
title_full_unstemmed The role of Hippo pathway in ferroptosis
title_short The role of Hippo pathway in ferroptosis
title_sort role of hippo pathway in ferroptosis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874674/
https://www.ncbi.nlm.nih.gov/pubmed/36713588
http://dx.doi.org/10.3389/fonc.2022.1107505
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