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Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features
BACKGROUND: Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer with poor prognosis, and its clinicopathological features are not well understood, so the pathology from the clinical biopsy is easily misdiagnosed, especially for special or atypical HAS. We present an extr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874694/ https://www.ncbi.nlm.nih.gov/pubmed/36713511 http://dx.doi.org/10.3389/fonc.2022.1016447 |
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author | Wu, Xinglong Di, Lianjun Li, Chengfang Zhang, Suyuan Tan, Na Huang, Jiajia Tuo, Biguang |
author_facet | Wu, Xinglong Di, Lianjun Li, Chengfang Zhang, Suyuan Tan, Na Huang, Jiajia Tuo, Biguang |
author_sort | Wu, Xinglong |
collection | PubMed |
description | BACKGROUND: Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer with poor prognosis, and its clinicopathological features are not well understood, so the pathology from the clinical biopsy is easily misdiagnosed, especially for special or atypical HAS. We present an extremely rare early HAS with signet ring cell carcinoma and evaluate its clinicopathological features. CASE PRESENTATION: A 51-year-old female patient of Chinese Han ethnicity with upper abdominal pain for 5 years and worsened abdominal pain for 1 month was admitted to our hospital. Esophagogastroduodenoscopy showed a submucosal tumor-like elevated lesion with central depression in the greater curvature of the junction between the antrum and body. Histopathological examination from the biopsy revealed medium–low-differentiation adenocarcinoma with signet ring cell carcinoma. Radical gastrectomy was performed, and the final diagnosis was early HAS with signet ring cell carcinoma. CONCLUSIONS: HAS with signet ring cell carcinoma is a special type of HAS and extremely rare. It is first presented for this extremely rare type of HAS, which contributes to strengthen the understanding for the clinicopathological characteristics of HAS and especially promote early detection of HAS. |
format | Online Article Text |
id | pubmed-9874694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98746942023-01-26 Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features Wu, Xinglong Di, Lianjun Li, Chengfang Zhang, Suyuan Tan, Na Huang, Jiajia Tuo, Biguang Front Oncol Oncology BACKGROUND: Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer with poor prognosis, and its clinicopathological features are not well understood, so the pathology from the clinical biopsy is easily misdiagnosed, especially for special or atypical HAS. We present an extremely rare early HAS with signet ring cell carcinoma and evaluate its clinicopathological features. CASE PRESENTATION: A 51-year-old female patient of Chinese Han ethnicity with upper abdominal pain for 5 years and worsened abdominal pain for 1 month was admitted to our hospital. Esophagogastroduodenoscopy showed a submucosal tumor-like elevated lesion with central depression in the greater curvature of the junction between the antrum and body. Histopathological examination from the biopsy revealed medium–low-differentiation adenocarcinoma with signet ring cell carcinoma. Radical gastrectomy was performed, and the final diagnosis was early HAS with signet ring cell carcinoma. CONCLUSIONS: HAS with signet ring cell carcinoma is a special type of HAS and extremely rare. It is first presented for this extremely rare type of HAS, which contributes to strengthen the understanding for the clinicopathological characteristics of HAS and especially promote early detection of HAS. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9874694/ /pubmed/36713511 http://dx.doi.org/10.3389/fonc.2022.1016447 Text en Copyright © 2023 Wu, Di, Li, Zhang, Tan, Huang and Tuo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wu, Xinglong Di, Lianjun Li, Chengfang Zhang, Suyuan Tan, Na Huang, Jiajia Tuo, Biguang Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title | Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title_full | Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title_fullStr | Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title_full_unstemmed | Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title_short | Early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: A case report and clinicopathological features |
title_sort | early hepatoid adenocarcinoma of the stomach with signet ring cell carcinoma: a case report and clinicopathological features |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874694/ https://www.ncbi.nlm.nih.gov/pubmed/36713511 http://dx.doi.org/10.3389/fonc.2022.1016447 |
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