Molecular insights into onset of autoimmunity in SARS‐CoV‐2 infected patients

Some of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infected patients are facing long‐term devastating effects like induction of autoimmune diseases. Here, I discuss molecular mechanisms and risk factors involved in the induction of autoimmune diseases after SARS‐CoV‐2 infections. Transcript editing genes were upregulated during SARS‐CoV‐2 infections, which might have edited host gene transcripts and paved the way for autoantigens generation and presented as nonself to generate autoantibodies followed by auto immunogenicity after SARS‐CoV‐2 infections. Therefore, some SARS‐CoV‐2 patients acquire autoimmunity. The transient and/or innocuous autoimmune response in some SARS‐CoV‐2 infected patients may be due to a lack of repeated production of autoantibodies to host autoantigens and/or viral antigens, which are needed to boost autoimmune response. In the future, SARS‐CoV‐2 mediated autoimmune disease onset will be a challenging task. Therefore, possible preventive measures and strategies to minimize and/or preclude such SARS‐CoV‐2 mediated autoimmune diseases have been presented in this commentary.