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Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile

TP53 is the most commonly mutated gene in cancer, and gain-of-function mutations have wide-ranging effects. Efforts to reactivate wild-type p53 function and inhibit mutant functions have been complicated by the variety of TP53 mutations. Identified from a screen, the NSC59984 compound has been shown...

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Detalles Bibliográficos
Autores principales:	Brown, Kate, Jenkins, Lisa M. Miller, Crooks, Daniel R., Surman, Deborah R., Mazur, Sharlyn J., Xu, Yuan, Arimilli, Bhargav S., Yang, Ye, Lane, Andrew N., Fan, Teresa W-M., Schrump, David S., Linehan, W. Marston, Ripley, R. Taylor, Appella, Ettore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874945/ https://www.ncbi.nlm.nih.gov/pubmed/36713582 http://dx.doi.org/10.3389/fonc.2022.1094210

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