Cargando…

Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis

BACKGROUND: Fibrosis is an important pathological process in the development of non-alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central event in liver fibrosis. However, the transcriptomic change of activated HSCs (aHSCs) and resting HSCs (rHSCs) in NASH...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Weiwei, Huang, Caoxin, Shi, Xiulin, Wu, Menghua, Li, Han, Liu, Qiuhong, Zhang, Xiaofang, Zhao, Yan, Li, Xuejun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874973/ https://www.ncbi.nlm.nih.gov/pubmed/36562664 http://dx.doi.org/10.1530/EC-22-0502

Ejemplares similares

Identifying a distinct fibrosis subset of NAFLD via molecular profiling and the involvement of profibrotic macrophages
por: He, Weiwei, et al.
Publicado: (2023)

Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones
por: Liu, Qiuhong, et al.
Publicado: (2022)

Corrigendum: Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones
por: Liu, Qiuhong, et al.
Publicado: (2023)

Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity
por: Wang, Dongmei, et al.
Publicado: (2022)

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis
por: McKee, Chad, et al.
Publicado: (2015)

Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Analysis of isolated hepatic stellate cells
por: KIM, MINA, et al.
Publicado: (2012)

Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis
por: Zhou, Zhou, et al.
Publicado: (2018)

The correlation between triiodothyronine and the severity of liver fibrosis
por: He, Weiwei, et al.
Publicado: (2022)

Pycnodysostosis with novel gene mutation and sporadic medullary thyroid carcinoma: A case report
por: Shi, Xiulin, et al.
Publicado: (2017)

Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis
por: Fred, Rikard G., et al.
Publicado: (2022)

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice
por: Xu, Liang, et al.
Publicado: (2018)

Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells
por: Han, Juqiang, et al.
Publicado: (2019)

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
por: Yenilmez, Batuhan, et al.
Publicado: (2023)

Serum metabolomic analysis of the effect of exercise on nonalcoholic fatty liver disease
por: Li, Jia, et al.
Publicado: (2019)

Screening and Identification of Key Genes for Activation of Islet Stellate Cell
por: Wang, Xiaohang, et al.
Publicado: (2021)

Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis
por: Yan, Mengli, et al.
Publicado: (2023)

Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice
por: Teratani, Toshiaki, et al.
Publicado: (2019)

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
por: Min, Kyounghee, et al.
Publicado: (2023)

Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma
por: Zhou, Yuan, et al.
Publicado: (2023)

Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model
por: DOUHARA, AKITOSHI, et al.
Publicado: (2015)

Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non‐alcoholic steatohepatitis (NASH)
por: Hada, Natsuko, et al.
Publicado: (2023)

Combined alcoholic and non-alcoholic steatohepatitis
por: Ntandja Wandji, Line Carolle, et al.
Publicado: (2020)

Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis
por: Li, Xian-Qian, et al.
Publicado: (2018)

The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
por: Hanayama, Masakazu, et al.
Publicado: (2021)

Immune cell-mediated features of non-alcoholic steatohepatitis
por: Huby, Thierry, et al.
Publicado: (2021)

Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma
por: Liu, Fei, et al.
Publicado: (2022)

Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis
por: Etienne, Quentin, et al.
Publicado: (2022)

Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators
por: Huisman, Christian, et al.
Publicado: (2019)

Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells
por: Wang, Tianxi, et al.
Publicado: (2018)

Hypoxia-Inducible Factors as Key Players in the Pathogenesis of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
por: Holzner, Lorenz M. W., et al.
Publicado: (2021)

Fructose and Non-Alcoholic Steatohepatitis
por: Roeb, Elke, et al.
Publicado: (2021)

Statins in Non-alcoholic Steatohepatitis
por: Torres-Peña, Jose D., et al.
Publicado: (2021)

Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis
por: Baker, Susan S., et al.
Publicado: (2010)

Innate Lymphoid Cells: New Culprits of Alcohol-Associated Steatohepatitis
por: Choi, Sung Eun, et al.
Publicado: (2022)

Non-alcoholic Steatohepatitis Pathogenesis, Diagnosis, and Treatment
por: Zhu, Bo, et al.
Publicado: (2021)

Non-ossifying fibroma with a pathologic fracture in a 12-year-old girl with tricho-rhino-phalangeal syndrome: a case report
por: Su, Weijuan, et al.
Publicado: (2018)

Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor
por: Boeckmans, Joost, et al.
Publicado: (2019)

A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
por: Wang, Xiaohang, et al.
Publicado: (2018)

Cytoskeleton—a crucial key in host cell for coronavirus infection
por: Wen, Zeyu, et al.
Publicado: (2020)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice
por: Kim, Kyung Eun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8u0clqs054pfpqt1do4e3hb7be