Cigarette smoke induces mitochondrial DNA damage and activates cGAS-STING pathway: application to a biomarker for atherosclerosis

Cigarette smoking is a major risk factor for atherosclerosis. We previously reported that DNA damage was accumulated in atherosclerotic plaque, and was increased in human mononuclear cells by smoking. As vascular endothelial cells are known to modulate inflammation, we investigated the mechanism by...

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Detalles Bibliográficos
Autores principales: Ueda, Keitaro, Sakai, Chiemi, Ishida, Takafumi, Morita, Kosuke, Kobayashi, Yusuke, Horikoshi, Yasunori, Baba, Akiko, Okazaki, Yuma, Yoshizumi, Masao, Tashiro, Satoshi, Ishida, Mari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Cardiovascular System & Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874975/
https://www.ncbi.nlm.nih.gov/pubmed/36598778
http://dx.doi.org/10.1042/CS20220525

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