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Metabolomics dissection of depression heterogeneity and related cardiometabolic risk

BACKGROUND: A recent hypothesis postulates the existence of an ‘immune-metabolic depression’ (IMD) dimension characterized by metabolic dysregulations. Combining data on metabolomics and depressive symptoms, we aimed to identify depressions associated with an increased risk of adverse metabolic alte...

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Autores principales: Alshehri, Tahani, Mook- Kanamori, Dennis O., Willems van Dijk, Ko, Dinga, Richard, Penninx, Brenda W. J. H., Rosendaal, Frits R., le Cessie, Saskia, Milaneschi, Yuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874986/
https://www.ncbi.nlm.nih.gov/pubmed/34078486
http://dx.doi.org/10.1017/S0033291721001471
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author Alshehri, Tahani
Mook- Kanamori, Dennis O.
Willems van Dijk, Ko
Dinga, Richard
Penninx, Brenda W. J. H.
Rosendaal, Frits R.
le Cessie, Saskia
Milaneschi, Yuri
author_facet Alshehri, Tahani
Mook- Kanamori, Dennis O.
Willems van Dijk, Ko
Dinga, Richard
Penninx, Brenda W. J. H.
Rosendaal, Frits R.
le Cessie, Saskia
Milaneschi, Yuri
author_sort Alshehri, Tahani
collection PubMed
description BACKGROUND: A recent hypothesis postulates the existence of an ‘immune-metabolic depression’ (IMD) dimension characterized by metabolic dysregulations. Combining data on metabolomics and depressive symptoms, we aimed to identify depressions associated with an increased risk of adverse metabolic alterations. METHOD: Clustering data were from 1094 individuals with major depressive disorder in the last 6 months and measures of 149 metabolites from a (1)H-NMR platform and 30 depressive symptoms (IDS-SR30). Canonical correlation analyses (CCA) were used to identify main independent metabolite-symptom axes of variance. Then, for the replication, we examined the association of the identified dimensions with metabolites from the same platform and cardiometabolic diseases in an independent population-based cohort (n = 6572). RESULTS: CCA identified an overall depression dimension and a dimension resembling IMD, in which symptoms such as sleeping too much, increased appetite, and low energy level had higher relative loading. In the independent sample, the overall depression dimension was associated with lower cardiometabolic risk, such as (i.e. per s.d.) HOMA-1B −0.06 (95% CI −0.09 – −0.04), and visceral adipose tissue −0.10 cm(2) (95% CI −0.14 – −0.07). In contrast, the IMD dimension was associated with well-known cardiometabolic diseases such as higher visceral adipose tissue 0.08 cm(2) (95% CI 0.04–0.12), HOMA-1B 0.06 (95% CI 0.04–0.09), and lower HDL-cholesterol levels −0.03 mmol/L (95% CI −0.05 – −0.01). CONCLUSIONS: Combining metabolomics and clinical symptoms we identified a replicable depression dimension associated with adverse metabolic alterations, in line with the IMD hypothesis. Patients with IMD may be at higher cardiometabolic risk and may benefit from specific treatment targeting underlying metabolic dysregulations.
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spelling pubmed-98749862023-02-02 Metabolomics dissection of depression heterogeneity and related cardiometabolic risk Alshehri, Tahani Mook- Kanamori, Dennis O. Willems van Dijk, Ko Dinga, Richard Penninx, Brenda W. J. H. Rosendaal, Frits R. le Cessie, Saskia Milaneschi, Yuri Psychol Med Original Article BACKGROUND: A recent hypothesis postulates the existence of an ‘immune-metabolic depression’ (IMD) dimension characterized by metabolic dysregulations. Combining data on metabolomics and depressive symptoms, we aimed to identify depressions associated with an increased risk of adverse metabolic alterations. METHOD: Clustering data were from 1094 individuals with major depressive disorder in the last 6 months and measures of 149 metabolites from a (1)H-NMR platform and 30 depressive symptoms (IDS-SR30). Canonical correlation analyses (CCA) were used to identify main independent metabolite-symptom axes of variance. Then, for the replication, we examined the association of the identified dimensions with metabolites from the same platform and cardiometabolic diseases in an independent population-based cohort (n = 6572). RESULTS: CCA identified an overall depression dimension and a dimension resembling IMD, in which symptoms such as sleeping too much, increased appetite, and low energy level had higher relative loading. In the independent sample, the overall depression dimension was associated with lower cardiometabolic risk, such as (i.e. per s.d.) HOMA-1B −0.06 (95% CI −0.09 – −0.04), and visceral adipose tissue −0.10 cm(2) (95% CI −0.14 – −0.07). In contrast, the IMD dimension was associated with well-known cardiometabolic diseases such as higher visceral adipose tissue 0.08 cm(2) (95% CI 0.04–0.12), HOMA-1B 0.06 (95% CI 0.04–0.09), and lower HDL-cholesterol levels −0.03 mmol/L (95% CI −0.05 – −0.01). CONCLUSIONS: Combining metabolomics and clinical symptoms we identified a replicable depression dimension associated with adverse metabolic alterations, in line with the IMD hypothesis. Patients with IMD may be at higher cardiometabolic risk and may benefit from specific treatment targeting underlying metabolic dysregulations. Cambridge University Press 2023-01 2021-06-03 /pmc/articles/PMC9874986/ /pubmed/34078486 http://dx.doi.org/10.1017/S0033291721001471 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Article
Alshehri, Tahani
Mook- Kanamori, Dennis O.
Willems van Dijk, Ko
Dinga, Richard
Penninx, Brenda W. J. H.
Rosendaal, Frits R.
le Cessie, Saskia
Milaneschi, Yuri
Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title_full Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title_fullStr Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title_full_unstemmed Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title_short Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
title_sort metabolomics dissection of depression heterogeneity and related cardiometabolic risk
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874986/
https://www.ncbi.nlm.nih.gov/pubmed/34078486
http://dx.doi.org/10.1017/S0033291721001471
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