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Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population

Burkitt's lymphoma (BL) is defined as a highly invasive B-cell lymphoma, usually characterized by an excellent prognosis, more than 90% of children and adolescents being cured with highly dose-intensive multiagent chemotherapy. Primary ovarian localization without involvement of other organs is...

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Autores principales: Persano, Giorgio, Crocoli, Alessandro, Martucci, Cristina, Vinti, Luciana, Cassanelli, Giulia, Stracuzzi, Alessandra, Cardoni, Antonello, Inserra, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875037/
https://www.ncbi.nlm.nih.gov/pubmed/36714645
http://dx.doi.org/10.3389/fped.2022.1072567
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author Persano, Giorgio
Crocoli, Alessandro
Martucci, Cristina
Vinti, Luciana
Cassanelli, Giulia
Stracuzzi, Alessandra
Cardoni, Antonello
Inserra, Alessandro
author_facet Persano, Giorgio
Crocoli, Alessandro
Martucci, Cristina
Vinti, Luciana
Cassanelli, Giulia
Stracuzzi, Alessandra
Cardoni, Antonello
Inserra, Alessandro
author_sort Persano, Giorgio
collection PubMed
description Burkitt's lymphoma (BL) is defined as a highly invasive B-cell lymphoma, usually characterized by an excellent prognosis, more than 90% of children and adolescents being cured with highly dose-intensive multiagent chemotherapy. Primary ovarian localization without involvement of other organs is a rare manifestation of BL, especially in pediatric population. Symptoms at diagnosis are similar to other ovarian lesions and differential diagnosis may be challenging for clinicians. A 12-year-old girl was referred to our institution for abdominal pain and palpable mass observed by the pediatrician. Diagnostic work-up demonstrated a large mass arising from the right ovary, causing compression on abdominal aorta, inferior vena cava, ureters and bowel, with a second smaller lesion on the left ovary. At surgery, a 15 cm-large, ruptured mass arising from the right ovary was found, associated with a second lesion originating from the left ovary (8 cm) and multiple nodules of the greater omentum. Right salpingo-oophorectomy was performed, incisional biopsies were taken from the left ovary and omental nodules and peritoneal fluid samples were collected for cytology. Pathology revealed a Burkitt lymphoma and the patient underwent chemotherapy according to AIEOP LNH-97 Protocol, group R3 with Rituximab. Preoperative diagnosis of primary ovarian lymphoma is extremely difficult. Surgical exploration is often necessary in patients presenting with acute abdominal or pelvic pain; when the suspicion of primary ovarian lymphoma arises intraoperatively, every effort should be made to minimize invasive procedure in order to enhance post-operative recovery.
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spelling pubmed-98750372023-01-26 Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population Persano, Giorgio Crocoli, Alessandro Martucci, Cristina Vinti, Luciana Cassanelli, Giulia Stracuzzi, Alessandra Cardoni, Antonello Inserra, Alessandro Front Pediatr Pediatrics Burkitt's lymphoma (BL) is defined as a highly invasive B-cell lymphoma, usually characterized by an excellent prognosis, more than 90% of children and adolescents being cured with highly dose-intensive multiagent chemotherapy. Primary ovarian localization without involvement of other organs is a rare manifestation of BL, especially in pediatric population. Symptoms at diagnosis are similar to other ovarian lesions and differential diagnosis may be challenging for clinicians. A 12-year-old girl was referred to our institution for abdominal pain and palpable mass observed by the pediatrician. Diagnostic work-up demonstrated a large mass arising from the right ovary, causing compression on abdominal aorta, inferior vena cava, ureters and bowel, with a second smaller lesion on the left ovary. At surgery, a 15 cm-large, ruptured mass arising from the right ovary was found, associated with a second lesion originating from the left ovary (8 cm) and multiple nodules of the greater omentum. Right salpingo-oophorectomy was performed, incisional biopsies were taken from the left ovary and omental nodules and peritoneal fluid samples were collected for cytology. Pathology revealed a Burkitt lymphoma and the patient underwent chemotherapy according to AIEOP LNH-97 Protocol, group R3 with Rituximab. Preoperative diagnosis of primary ovarian lymphoma is extremely difficult. Surgical exploration is often necessary in patients presenting with acute abdominal or pelvic pain; when the suspicion of primary ovarian lymphoma arises intraoperatively, every effort should be made to minimize invasive procedure in order to enhance post-operative recovery. Frontiers Media S.A. 2023-01-11 /pmc/articles/PMC9875037/ /pubmed/36714645 http://dx.doi.org/10.3389/fped.2022.1072567 Text en © 2023 Persano, Crocoli, Martucci, Vinti, Cassanelli, Stracuzzi, Cardoni and Inserra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Persano, Giorgio
Crocoli, Alessandro
Martucci, Cristina
Vinti, Luciana
Cassanelli, Giulia
Stracuzzi, Alessandra
Cardoni, Antonello
Inserra, Alessandro
Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title_full Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title_fullStr Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title_full_unstemmed Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title_short Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population
title_sort case report: primary ovarian burkitt's lymphoma: a puzzling scenario in pediatric population
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875037/
https://www.ncbi.nlm.nih.gov/pubmed/36714645
http://dx.doi.org/10.3389/fped.2022.1072567
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