Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations

BACKGROUND: The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation to other populations. Here, we aimed to generate a PRS by...

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Detalles Bibliográficos
Autores principales: Xin, Junyi, Du, Mulong, Gu, Dongying, Jiang, Kewei, Wang, Mengyun, Jin, Mingjuan, Hu, Yeting, Ben, Shuai, Chen, Silu, Shao, Wei, Li, Shuwei, Chu, Haiyan, Zhu, Linjun, Li, Chen, Chen, Kun, Ding, Kefeng, Zhang, Zhengdong, Shen, Hongbing, Wang, Meilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875451/
https://www.ncbi.nlm.nih.gov/pubmed/36694225
http://dx.doi.org/10.1186/s13073-023-01156-9

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