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Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer

BACKGROUND: The Mesenchymal epithelial transition factor (MET) gene encodes a receptor tyrosine kinase with pleiotropic functions in cancer. MET exon 14 skipping alterations and high-level MET amplification are oncogenic and targetable genetic changes in patients with non-small-cell lung cancer (NSC...

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Detalles Bibliográficos
Autores principales:	Yao, Yu, Yang, Huaping, Zhu, Bo, Wang, Song, Pang, Jiaohui, Wu, Xiaoying, Xu, Yang, Zhang, Junli, Zhang, Jinfeng, Ou, Qiuxiang, Tian, Hui, Zhao, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875465/ https://www.ncbi.nlm.nih.gov/pubmed/36698189 http://dx.doi.org/10.1186/s12931-023-02329-1

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