TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma

BACKGROUND: Systemic sclerosis is a rheumatoid disease best known for its fibrotic skin manifestations called scleroderma. Alternatively activated (M2-type) macrophages are normally involved in the resolution of inflammation and wound healing but also in fibrosing diseases such as scleroderma. TRPA1...

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Detalles Bibliográficos
Autores principales: Mäki-Opas, Ilari, Hämäläinen, Mari, Moilanen, Eeva, Scotece, Morena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875496/
https://www.ncbi.nlm.nih.gov/pubmed/36698198
http://dx.doi.org/10.1186/s13075-023-02994-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875496/
https://www.ncbi.nlm.nih.gov/pubmed/36698198
http://dx.doi.org/10.1186/s13075-023-02994-z

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