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The influence of different glucose tolerance on QTc interval: a population-based study
BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875502/ https://www.ncbi.nlm.nih.gov/pubmed/36698056 http://dx.doi.org/10.1186/s12872-023-03081-6 |
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author | Lin, Ning Zhang, Hongmei Li, Xiaoyong Niu, Yixin Gu, Hongxia Lu, Shuai Yang, Zhen Su, Qing Qin, Li |
author_facet | Lin, Ning Zhang, Hongmei Li, Xiaoyong Niu, Yixin Gu, Hongxia Lu, Shuai Yang, Zhen Su, Qing Qin, Li |
author_sort | Lin, Ning |
collection | PubMed |
description | BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance. RESULTS: QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126–1.730), and 1.342 for type 2 diabetes (95% CI 0.142–1.577) after all potential confounders were adjusted. CONCLUSIONS: Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population. |
format | Online Article Text |
id | pubmed-9875502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98755022023-01-26 The influence of different glucose tolerance on QTc interval: a population-based study Lin, Ning Zhang, Hongmei Li, Xiaoyong Niu, Yixin Gu, Hongxia Lu, Shuai Yang, Zhen Su, Qing Qin, Li BMC Cardiovasc Disord Research BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance. RESULTS: QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126–1.730), and 1.342 for type 2 diabetes (95% CI 0.142–1.577) after all potential confounders were adjusted. CONCLUSIONS: Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population. BioMed Central 2023-01-25 /pmc/articles/PMC9875502/ /pubmed/36698056 http://dx.doi.org/10.1186/s12872-023-03081-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lin, Ning Zhang, Hongmei Li, Xiaoyong Niu, Yixin Gu, Hongxia Lu, Shuai Yang, Zhen Su, Qing Qin, Li The influence of different glucose tolerance on QTc interval: a population-based study |
title | The influence of different glucose tolerance on QTc interval: a population-based study |
title_full | The influence of different glucose tolerance on QTc interval: a population-based study |
title_fullStr | The influence of different glucose tolerance on QTc interval: a population-based study |
title_full_unstemmed | The influence of different glucose tolerance on QTc interval: a population-based study |
title_short | The influence of different glucose tolerance on QTc interval: a population-based study |
title_sort | influence of different glucose tolerance on qtc interval: a population-based study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875502/ https://www.ncbi.nlm.nih.gov/pubmed/36698056 http://dx.doi.org/10.1186/s12872-023-03081-6 |
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