Cargando…

The influence of different glucose tolerance on QTc interval: a population-based study

BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that i...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Ning, Zhang, Hongmei, Li, Xiaoyong, Niu, Yixin, Gu, Hongxia, Lu, Shuai, Yang, Zhen, Su, Qing, Qin, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875502/
https://www.ncbi.nlm.nih.gov/pubmed/36698056
http://dx.doi.org/10.1186/s12872-023-03081-6
_version_ 1784877973952790528
author Lin, Ning
Zhang, Hongmei
Li, Xiaoyong
Niu, Yixin
Gu, Hongxia
Lu, Shuai
Yang, Zhen
Su, Qing
Qin, Li
author_facet Lin, Ning
Zhang, Hongmei
Li, Xiaoyong
Niu, Yixin
Gu, Hongxia
Lu, Shuai
Yang, Zhen
Su, Qing
Qin, Li
author_sort Lin, Ning
collection PubMed
description BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance. RESULTS: QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126–1.730), and 1.342 for type 2 diabetes (95% CI 0.142–1.577) after all potential confounders were adjusted. CONCLUSIONS: Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population.
format Online
Article
Text
id pubmed-9875502
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-98755022023-01-26 The influence of different glucose tolerance on QTc interval: a population-based study Lin, Ning Zhang, Hongmei Li, Xiaoyong Niu, Yixin Gu, Hongxia Lu, Shuai Yang, Zhen Su, Qing Qin, Li BMC Cardiovasc Disord Research BACKGROUND: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance. RESULTS: QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126–1.730), and 1.342 for type 2 diabetes (95% CI 0.142–1.577) after all potential confounders were adjusted. CONCLUSIONS: Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population. BioMed Central 2023-01-25 /pmc/articles/PMC9875502/ /pubmed/36698056 http://dx.doi.org/10.1186/s12872-023-03081-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lin, Ning
Zhang, Hongmei
Li, Xiaoyong
Niu, Yixin
Gu, Hongxia
Lu, Shuai
Yang, Zhen
Su, Qing
Qin, Li
The influence of different glucose tolerance on QTc interval: a population-based study
title The influence of different glucose tolerance on QTc interval: a population-based study
title_full The influence of different glucose tolerance on QTc interval: a population-based study
title_fullStr The influence of different glucose tolerance on QTc interval: a population-based study
title_full_unstemmed The influence of different glucose tolerance on QTc interval: a population-based study
title_short The influence of different glucose tolerance on QTc interval: a population-based study
title_sort influence of different glucose tolerance on qtc interval: a population-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875502/
https://www.ncbi.nlm.nih.gov/pubmed/36698056
http://dx.doi.org/10.1186/s12872-023-03081-6
work_keys_str_mv AT linning theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT zhanghongmei theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT lixiaoyong theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT niuyixin theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT guhongxia theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT lushuai theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT yangzhen theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT suqing theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT qinli theinfluenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT linning influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT zhanghongmei influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT lixiaoyong influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT niuyixin influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT guhongxia influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT lushuai influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT yangzhen influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT suqing influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy
AT qinli influenceofdifferentglucosetoleranceonqtcintervalapopulationbasedstudy