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Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through...

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Autores principales: Imani, Iman M., Kim, Bosung, Xiao, Xiao, Rubab, Najaf, Park, Byung‐Joon, Kim, Young‐Jun, Zhao, Pin, Kang, Minki, Kim, Sang‐Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875681/
https://www.ncbi.nlm.nih.gov/pubmed/36437039
http://dx.doi.org/10.1002/advs.202204801
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author Imani, Iman M.
Kim, Bosung
Xiao, Xiao
Rubab, Najaf
Park, Byung‐Joon
Kim, Young‐Jun
Zhao, Pin
Kang, Minki
Kim, Sang‐Woo
author_facet Imani, Iman M.
Kim, Bosung
Xiao, Xiao
Rubab, Najaf
Park, Byung‐Joon
Kim, Young‐Jun
Zhao, Pin
Kang, Minki
Kim, Sang‐Woo
author_sort Imani, Iman M.
collection PubMed
description To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)‐driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV‐TENG). After a programmed lifetime, the IBV‐TENG can be eliminated by provoking the on‐demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV‐TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV‐TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue.
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spelling pubmed-98756812023-01-25 Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity Imani, Iman M. Kim, Bosung Xiao, Xiao Rubab, Najaf Park, Byung‐Joon Kim, Young‐Jun Zhao, Pin Kang, Minki Kim, Sang‐Woo Adv Sci (Weinh) Research Articles To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge. This work proposes a new strategy to eliminate microorganisms of deep tissue through electrical stimulation with an ultrasound (US)‐driven implantable, biodegradable, and vibrant triboelectric nanogenerator (IBV‐TENG). After a programmed lifetime, the IBV‐TENG can be eliminated by provoking the on‐demand device dissolution by controlling US intensity with no surgical removal of the device from the body. A voltage of ≈4 V and current of ≈22 µA generated from IBV‐TENG under ultrasound in vitro, confirming inactivating ≈100% of Staphylococcus aureus and ≈99% of Escherichia coli. Furthermore, ex vivo results show that IBV‐TENG implanted under porcine tissue successfully inactivates bacteria. This antibacterial technology is expected to be a countermeasure strategy against SSIs, increasing life expectancy and healthcare quality by preventing microorganisms of deep tissue. John Wiley and Sons Inc. 2022-11-27 /pmc/articles/PMC9875681/ /pubmed/36437039 http://dx.doi.org/10.1002/advs.202204801 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Imani, Iman M.
Kim, Bosung
Xiao, Xiao
Rubab, Najaf
Park, Byung‐Joon
Kim, Young‐Jun
Zhao, Pin
Kang, Minki
Kim, Sang‐Woo
Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title_full Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title_fullStr Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title_full_unstemmed Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title_short Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity
title_sort ultrasound‐driven on‐demand transient triboelectric nanogenerator for subcutaneous antibacterial activity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875681/
https://www.ncbi.nlm.nih.gov/pubmed/36437039
http://dx.doi.org/10.1002/advs.202204801
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