CD4(+) T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1–Dependent

RATIONALE: Lymphopenia is common in severe coronavirus disease (COVID-19), yet the immune mechanisms are poorly understood. As inflammatory cytokines are increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we hypothesized a role in contributing to reduced T-cell numb...

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Detalles Bibliográficos
Autores principales: Popescu, Iulia, Snyder, Mark E., Iasella, Carlo J., Hannan, Stefanie J., Koshy, Ritchie, Burke, Robin, Das, Antu, Brown, Mark J., Lyons, Emily J., Lieber, Sophia C., Chen, Xiaoping, Sembrat, John C., Bhatt, Payal, Deng, Evan, An, Xiaojing, Linstrum, Kelsey, Kitsios, Georgios, Konstantinidis, Ioannis, Saul, Melissa, Kass, Daniel J., Alder, Jonathan K., Chen, Bill B., Lendermon, Elizabeth A., Kilaru, Silpa, Johnson, Bruce, Pilewski, Joseph M., Kiss, Joseph E., Wells, Alan H., Morris, Alison, McVerry, Bryan J., McMahon, Deborah K., Triulzi, Darrell J., Chen, Kong, Sanchez, Pablo G., McDyer, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875894/
https://www.ncbi.nlm.nih.gov/pubmed/35348444
http://dx.doi.org/10.1164/rccm.202111-2493OC

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