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Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival

Osteosarcoma (OS) is a malignant tumor originating from the mesenchymal tissue. Simultaneous reports of lung and bone metastases (BM) in OS are rare in the literature. A total of 353 new cases of lung metastases (LM), 93 new cases of BM, and 59 new cases of LM and BM were diagnosed in the Surveillan...

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Autores principales: Tang, Liyuan, Liu, Binbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875956/
https://www.ncbi.nlm.nih.gov/pubmed/36705375
http://dx.doi.org/10.1097/MD.0000000000032692
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author Tang, Liyuan
Liu, Binbin
author_facet Tang, Liyuan
Liu, Binbin
author_sort Tang, Liyuan
collection PubMed
description Osteosarcoma (OS) is a malignant tumor originating from the mesenchymal tissue. Simultaneous reports of lung and bone metastases (BM) in OS are rare in the literature. A total of 353 new cases of lung metastases (LM), 93 new cases of BM, and 59 new cases of LM and BM were diagnosed in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2019. Univariate and multivariate logistic regression analyses were used to identify risk factors for LM and/or BM, and Cox regression analyses were performed to identify the prognostic factors for LM and/or BM. Kaplan–Meier (K–M) curves and log-rank tests were used to analyze the overall survival of patients with LM and/or BM. LM was diagnosed in 353 patients. Female sex, tumor size >100 mm, telangiectatic OS type, central OS type, N1 stage, other locations, BM, surgical treatments, radiotherapy and chemotherapy were significantly correlated with LM. 93 patients were diagnosed with BM. 25 to 59 years old, T1 stage, presence of LM, liver metastases, radiotherapy, and surgical treatments were significantly correlated with the BM. 59 patients were diagnosed with LM and BM. The chondroblastic OS type, small cell OS type, T1 stage, N1 stage, other locations, liver metastases, radiotherapy, and surgical treatments were significantly correlated with LM and BM. Metastases, radiotherapy, and surgery at the primary site were significantly associated with LM and/or BM. Chemotherapy at the primary site has been shown to be effective in improving the survival rate of LM and/or BM. Of the OS patients with LM, 61.47% died, and older age, BM, no surgery, and no chemotherapy were harmful to survival. 72.04% of OS patients with BM died, and N1 stage, no surgery, and no chemotherapy were harmful for survival. 69.49% of OS patients with LM and BM died, and older age and no chemotherapy were harmful for survival.
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spelling pubmed-98759562023-01-27 Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival Tang, Liyuan Liu, Binbin Medicine (Baltimore) 5700 Osteosarcoma (OS) is a malignant tumor originating from the mesenchymal tissue. Simultaneous reports of lung and bone metastases (BM) in OS are rare in the literature. A total of 353 new cases of lung metastases (LM), 93 new cases of BM, and 59 new cases of LM and BM were diagnosed in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2019. Univariate and multivariate logistic regression analyses were used to identify risk factors for LM and/or BM, and Cox regression analyses were performed to identify the prognostic factors for LM and/or BM. Kaplan–Meier (K–M) curves and log-rank tests were used to analyze the overall survival of patients with LM and/or BM. LM was diagnosed in 353 patients. Female sex, tumor size >100 mm, telangiectatic OS type, central OS type, N1 stage, other locations, BM, surgical treatments, radiotherapy and chemotherapy were significantly correlated with LM. 93 patients were diagnosed with BM. 25 to 59 years old, T1 stage, presence of LM, liver metastases, radiotherapy, and surgical treatments were significantly correlated with the BM. 59 patients were diagnosed with LM and BM. The chondroblastic OS type, small cell OS type, T1 stage, N1 stage, other locations, liver metastases, radiotherapy, and surgical treatments were significantly correlated with LM and BM. Metastases, radiotherapy, and surgery at the primary site were significantly associated with LM and/or BM. Chemotherapy at the primary site has been shown to be effective in improving the survival rate of LM and/or BM. Of the OS patients with LM, 61.47% died, and older age, BM, no surgery, and no chemotherapy were harmful to survival. 72.04% of OS patients with BM died, and N1 stage, no surgery, and no chemotherapy were harmful for survival. 69.49% of OS patients with LM and BM died, and older age and no chemotherapy were harmful for survival. Lippincott Williams & Wilkins 2023-01-27 /pmc/articles/PMC9875956/ /pubmed/36705375 http://dx.doi.org/10.1097/MD.0000000000032692 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Tang, Liyuan
Liu, Binbin
Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title_full Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title_fullStr Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title_full_unstemmed Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title_short Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
title_sort lung and bone metastases patterns in osteosarcoma: chemotherapy improves overall survival
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875956/
https://www.ncbi.nlm.nih.gov/pubmed/36705375
http://dx.doi.org/10.1097/MD.0000000000032692
work_keys_str_mv AT tangliyuan lungandbonemetastasespatternsinosteosarcomachemotherapyimprovesoverallsurvival
AT liubinbin lungandbonemetastasespatternsinosteosarcomachemotherapyimprovesoverallsurvival