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A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea

Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause serious infection. We aimed to analyze the prevalence and susceptibility rates to trimethoprim/sulfamethoxazole of S. maltophilia. We conducted a retrospective study of S. maltophilia isolates from a university hos...

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Autores principales: Song, Je Eun, Kim, Sollip, Kwak, Yee Gyung, Shin, Sunghwan, Um, Tae-Hyun, Cho, Chong Rae, Chang, Jeonghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875982/
https://www.ncbi.nlm.nih.gov/pubmed/36705390
http://dx.doi.org/10.1097/MD.0000000000032704
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author Song, Je Eun
Kim, Sollip
Kwak, Yee Gyung
Shin, Sunghwan
Um, Tae-Hyun
Cho, Chong Rae
Chang, Jeonghyun
author_facet Song, Je Eun
Kim, Sollip
Kwak, Yee Gyung
Shin, Sunghwan
Um, Tae-Hyun
Cho, Chong Rae
Chang, Jeonghyun
author_sort Song, Je Eun
collection PubMed
description Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause serious infection. We aimed to analyze the prevalence and susceptibility rates to trimethoprim/sulfamethoxazole of S. maltophilia. We conducted a retrospective study of S. maltophilia isolates from a university hospital from 2001 to 2020. Clinical information, the numbers of isolates and susceptibility rates were analyzed by year. Susceptibility rates and changes in respiratory and non-respiratory samples were compared. 1805 S. maltophilia isolates were identified, of which 81.4% (1469/1805) were from respiratory samples. There was a male predominance and 52% of the isolates were from general wards. The average susceptibility rate was 87.7% and there was no significant annual trend (P = .519). The susceptibility rate was 88.7% in respiratory samples and 84.1% in non-respiratory samples (P = .018). Susceptibility analyses using clinical data over long periods can guide the choice of antimicrobials especially for pathogen whose treatment options are limited.
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spelling pubmed-98759822023-01-27 A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea Song, Je Eun Kim, Sollip Kwak, Yee Gyung Shin, Sunghwan Um, Tae-Hyun Cho, Chong Rae Chang, Jeonghyun Medicine (Baltimore) 4400 Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause serious infection. We aimed to analyze the prevalence and susceptibility rates to trimethoprim/sulfamethoxazole of S. maltophilia. We conducted a retrospective study of S. maltophilia isolates from a university hospital from 2001 to 2020. Clinical information, the numbers of isolates and susceptibility rates were analyzed by year. Susceptibility rates and changes in respiratory and non-respiratory samples were compared. 1805 S. maltophilia isolates were identified, of which 81.4% (1469/1805) were from respiratory samples. There was a male predominance and 52% of the isolates were from general wards. The average susceptibility rate was 87.7% and there was no significant annual trend (P = .519). The susceptibility rate was 88.7% in respiratory samples and 84.1% in non-respiratory samples (P = .018). Susceptibility analyses using clinical data over long periods can guide the choice of antimicrobials especially for pathogen whose treatment options are limited. Lippincott Williams & Wilkins 2023-01-27 /pmc/articles/PMC9875982/ /pubmed/36705390 http://dx.doi.org/10.1097/MD.0000000000032704 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4400
Song, Je Eun
Kim, Sollip
Kwak, Yee Gyung
Shin, Sunghwan
Um, Tae-Hyun
Cho, Chong Rae
Chang, Jeonghyun
A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title_full A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title_fullStr A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title_full_unstemmed A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title_short A 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of Stenotrophomonas maltophilia in a single secondary care hospital in Korea
title_sort 20-year trend of prevalence and susceptibility to trimethoprim/sulfamethoxazole of stenotrophomonas maltophilia in a single secondary care hospital in korea
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875982/
https://www.ncbi.nlm.nih.gov/pubmed/36705390
http://dx.doi.org/10.1097/MD.0000000000032704
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