Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice

Aristolochic acid I (AAI) is a well established nephrotoxin and human carcinogen. Cytosolic NAD(P)H quinone oxidoreductase 1 (NQO1) plays an important role in the nitro reduction of aristolochic acids, leading to production of aristoloactam and AA-DNA adduct. Application of a potent NQO1 inhibitor d...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Ya-ping, Chen, Shu-zhen, He, Hui-si, Sun, Zhuo-ran, Jiang, Li-xuan, Gu, Yan-qiu, Zhang, Ying, Feng, Fei, Chen, Chun, Fan, Zhe-cai, Chen, Xiao-fei, Wen, Wen, Wang, Hong-yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876410/
https://www.ncbi.nlm.nih.gov/pubmed/36697978
http://dx.doi.org/10.1038/s41401-023-01052-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876410/
https://www.ncbi.nlm.nih.gov/pubmed/36697978
http://dx.doi.org/10.1038/s41401-023-01052-3

Ejemplares similares