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Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice

Aristolochic acid I (AAI) is a well established nephrotoxin and human carcinogen. Cytosolic NAD(P)H quinone oxidoreductase 1 (NQO1) plays an important role in the nitro reduction of aristolochic acids, leading to production of aristoloactam and AA-DNA adduct. Application of a potent NQO1 inhibitor d...

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Detalles Bibliográficos
Autores principales:	Dong, Ya-ping, Chen, Shu-zhen, He, Hui-si, Sun, Zhuo-ran, Jiang, Li-xuan, Gu, Yan-qiu, Zhang, Ying, Feng, Fei, Chen, Chun, Fan, Zhe-cai, Chen, Xiao-fei, Wen, Wen, Wang, Hong-yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876410/ https://www.ncbi.nlm.nih.gov/pubmed/36697978 http://dx.doi.org/10.1038/s41401-023-01052-3

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