RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8

Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here, we show that T cell–specific RIPK1 deficiency in mice leads to the premature senescence of T cells and induces various age-related diseases, resulting in premature death. RIPK1 deficiency causes higher basal a...

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Detalles Bibliográficos
Autores principales: Imanishi, Takayuki, Unno, Midori, Yoneda, Natsumi, Motomura, Yasutaka, Mochizuki, Miho, Sasaki, Takaharu, Pasparakis, Manolis, Saito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876550/
https://www.ncbi.nlm.nih.gov/pubmed/36696505
http://dx.doi.org/10.1126/sciadv.add6097

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