Inhibition of the proton-activated chloride channel PAC by PIP(2)

Proton-activated chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel, encoded by PACC1 (TMEM206). PAC regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens. It is also found at the cell surface, where it is activated under...

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Detalles Bibliográficos
Autores principales: Mihaljević, Ljubica, Ruan, Zheng, Osei-Owusu, James, Lü, Wei, Qiu, Zhaozhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876566/
https://www.ncbi.nlm.nih.gov/pubmed/36633397
http://dx.doi.org/10.7554/eLife.83935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876566/
https://www.ncbi.nlm.nih.gov/pubmed/36633397
http://dx.doi.org/10.7554/eLife.83935

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