GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel genetic factors that evoke drug resistance. In addition to the know...

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Detalles Bibliográficos
Autores principales: Naz, Saba, Paritosh, Kumar, Sanyal, Priyadarshini, Khan, Sidra, Singh, Yogendra, Varshney, Umesh, Nandicoori, Vinay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876569/
https://www.ncbi.nlm.nih.gov/pubmed/36695572
http://dx.doi.org/10.7554/eLife.75860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876569/
https://www.ncbi.nlm.nih.gov/pubmed/36695572
http://dx.doi.org/10.7554/eLife.75860

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