IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome

Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by stunted growth, cognitive impairment, and increased risk of diverse neurological conditions. Although signs of lifelong neurodegeneration are well documented in DS, the mechanisms underlying this phenotype awai...

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Detalles Bibliográficos
Autores principales: Araya, Paula, Kinning, Kohl T., Coughlan, Christina, Smith, Keith P., Granrath, Ross E., Enriquez-Estrada, Belinda A., Worek, Kayleigh, Sullivan, Kelly D., Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Galbraith, Matthew D., Potter, Huntington, Espinosa, Joaquin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876612/
https://www.ncbi.nlm.nih.gov/pubmed/36577365
http://dx.doi.org/10.1016/j.celrep.2022.111883

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