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Gastro-colic Fistula-associated Hypersplenism Causes Pancytopenia in a Patient with Crohn's Disease

A 24-year-old woman was admitted to our hospital due to abdominal pain and a high fever. She was diagnosed with ileocolonic Crohn's disease (CD), complicated with a gastro-colic fistula and splenomegaly. After initial treatment with an infliximab-biosimilar, all blood cell line counts markedly...

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Detalles Bibliográficos
Autores principales: Saito, Seisuke, Ueno, Nobuhiro, Kamikokura, Yuki, Sugiyama, Yuya, Kobayashi, Yu, Murakami, Yuki, Kunogi, Takehito, Sasaki, Takahiro, Takahashi, Keitaro, Ando, Katsuyoshi, Kashima, Shin, Moriichi, Kentaro, Tanabe, Hiroki, Tanino, Mishie, Okumura, Toshikatsu, Fujiya, Mikihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876717/
https://www.ncbi.nlm.nih.gov/pubmed/35598997
http://dx.doi.org/10.2169/internalmedicine.9590-22
Descripción
Sumario:A 24-year-old woman was admitted to our hospital due to abdominal pain and a high fever. She was diagnosed with ileocolonic Crohn's disease (CD), complicated with a gastro-colic fistula and splenomegaly. After initial treatment with an infliximab-biosimilar, all blood cell line counts markedly decreased. Three-dimensional reconstructed computed tomography revealed splenic vein narrowing. Thus, her pancytopenia was deemed to have likely been caused by hypersplenism. Surgery was performed, and clinical remission was maintained without pancytopenia. This is the first report of a CD patient with pancytopenia caused by hypersplenism that was triggered by gastro-colic fistula-associated splenic vein obstruction.