Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions

A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On d...

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Autores principales: Hidaka, Masaoki, Kumamoto, Masaya, Suenaga, Tatsuya, Itsuji, Ayaka, Kanazawa, Yuka, Goto, Seiji, Takaba, Hitonori, Kitazono, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876722/
https://www.ncbi.nlm.nih.gov/pubmed/35598991
http://dx.doi.org/10.2169/internalmedicine.8910-21
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author Hidaka, Masaoki
Kumamoto, Masaya
Suenaga, Tatsuya
Itsuji, Ayaka
Kanazawa, Yuka
Goto, Seiji
Takaba, Hitonori
Kitazono, Takanari
author_facet Hidaka, Masaoki
Kumamoto, Masaya
Suenaga, Tatsuya
Itsuji, Ayaka
Kanazawa, Yuka
Goto, Seiji
Takaba, Hitonori
Kitazono, Takanari
author_sort Hidaka, Masaoki
collection PubMed
description A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions.
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spelling pubmed-98767222023-02-02 Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions Hidaka, Masaoki Kumamoto, Masaya Suenaga, Tatsuya Itsuji, Ayaka Kanazawa, Yuka Goto, Seiji Takaba, Hitonori Kitazono, Takanari Intern Med Case Report A 30-year-old man admitted with renal dysfunction (serum creatinine, 8.19 mg/dL) was diagnosed with immunoglobulin A nephritis through a renal biopsy. He was treated with intravenous methylprednisolone pulse therapy and urgent hemodialysis, and eventually, he underwent maintenance hemodialysis. On day 108, he developed amnesia. Magnetic resonance imaging revealed bilateral basal ganglia lesions. Wernicke encephalopathy (WE) was diagnosed based on decreased serum thiamine concentration (12.8 μg/dL; reference range, 24-66 μg/dL). Thiamine replacement therapy was initiated, but the Wernicke-Korsakoff syndrome persisted. Careful monitoring of thiamine is required in patients undergoing dialysis. In addition, patients with WE may exhibit bilateral basal ganglia lesions. The Japanese Society of Internal Medicine 2022-05-21 2023-01-01 /pmc/articles/PMC9876722/ /pubmed/35598991 http://dx.doi.org/10.2169/internalmedicine.8910-21 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hidaka, Masaoki
Kumamoto, Masaya
Suenaga, Tatsuya
Itsuji, Ayaka
Kanazawa, Yuka
Goto, Seiji
Takaba, Hitonori
Kitazono, Takanari
Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title_full Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title_fullStr Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title_full_unstemmed Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title_short Wernicke-Korsakoff Syndrome in a Young Adult on Dialysis Who Showed Bilateral Ganglia Lesions
title_sort wernicke-korsakoff syndrome in a young adult on dialysis who showed bilateral ganglia lesions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876722/
https://www.ncbi.nlm.nih.gov/pubmed/35598991
http://dx.doi.org/10.2169/internalmedicine.8910-21
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