Does supplementation of oocytes with additional mtDNA influence developmental outcome?

Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor quality oocytes. However, supplementation alters DNA methylation and gene expression profiles of preimplantation embryos. To determine if these alterations impacted offspring, we introduced mtDNA from failed-to...

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Detalles Bibliográficos
Autores principales: McIlfatrick, Stephen, O’Leary, Sean, Okada, Takashi, Penn, Alexander, Nguyen, Vy Hoang Thao, McKenny, Lisa, Huang, Shang-Yu, Andreas, Eryk, Finnie, John, Kirkwood, Roy, St. John, Justin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876745/
https://www.ncbi.nlm.nih.gov/pubmed/36711242
http://dx.doi.org/10.1016/j.isci.2023.105956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876745/
https://www.ncbi.nlm.nih.gov/pubmed/36711242
http://dx.doi.org/10.1016/j.isci.2023.105956

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