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N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells

Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent reaction intermediate that is the target of the camptothecin class of chemotherapeutics. Tdp1 two-step catalysis is centered on the formation o...

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Detalles Bibliográficos
Autores principales:	Brettrager, Evan J., Cuya, Selma M., Tibbs, Zachary E., Zhang, Jun, Falany, Charles N., Aller, Stephen G., van Waardenburg, Robert C. A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876888/ https://www.ncbi.nlm.nih.gov/pubmed/36697463 http://dx.doi.org/10.1038/s41598-023-28564-6

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