Novel N-benzyl-2-oxo-1,2-dihydrofuro [3,4-d]pyrimidine-3(4H)-carboxamide as anticancer agent: Synthesis, drug-likeness, ADMET profile, DFT and molecular modelling against EGFR target

A novel compound N-benzyl-2-oxo-1,2-dihydrofuro [3,4-d]pyrimidine-3(4H)-carboxamide (DHFP) was synthesized by addition, rearrangement, and intramolecular cyclization reactions. The three-dimensional geometry of DHFP has been determined by density functional theory calculations in the gas phase. Thus...

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Detalles Bibliográficos
Autores principales: Şuekinci Yılmaz, Ayşen, Uluçam, Gühergül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876965/
https://www.ncbi.nlm.nih.gov/pubmed/36711281
http://dx.doi.org/10.1016/j.heliyon.2023.e12948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876965/
https://www.ncbi.nlm.nih.gov/pubmed/36711281
http://dx.doi.org/10.1016/j.heliyon.2023.e12948

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