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Expression and clinical significance of short-chain fatty acids in pregnancy complications
OBJECTIVE: To investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance. METHODS: Targeted metabo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876977/ https://www.ncbi.nlm.nih.gov/pubmed/36710961 http://dx.doi.org/10.3389/fcimb.2022.1071029 |
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author | Chen, Siqian Li, Jialin Ren, Shuaijun Gao, Yajie Zhou, Yuping Xuan, Rongrong |
author_facet | Chen, Siqian Li, Jialin Ren, Shuaijun Gao, Yajie Zhou, Yuping Xuan, Rongrong |
author_sort | Chen, Siqian |
collection | PubMed |
description | OBJECTIVE: To investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance. METHODS: Targeted metabonomics was used to detect SCFAs in the serum of 28 GDM pregnant women, 28 PE pregnant women, 29 ICP pregnant women, and 27 healthy pregnant women (NP); their expression changes were observed; the correlation between SCFAs and clinical characteristics was studied; and their potential as biomarkers for clinical diagnosis was evaluated. RESULTS: There were significant differences in the SCFA metabolic spectrum between the GDM, PE, ICP, and NP groups. Quantitative analysis showed that the content of isobutyric acid in the three pregnancy complications groups (the GDM, PE, and ICP groups) was significantly higher than that in the NP group (p < 0.05), and other SCFAs also showed significant differences in the three pregnancy complications groups compared with the NP group (p < 0.05). Receiver operating characteristic (ROC) curve analysis of the generalized linear model showed that multiple SCFAs were highly sensitive and specific as diagnostic markers in the pregnancy complications groups, where isobutyric acid was highly predictive in GDM (area under the ROC curve (AUC) = 0.764) and PE (AUC = 1), and caproic acid was highly predictive in ICP (AUC = 0.968), with potential clinical application. CONCLUSION: The metabolic products of intestinal flora, SCFAs, during pregnancy are closely related to pregnancy complications (GDM, PE, and ICP), and SCFAs can be used as potential markers of pregnancy complications. |
format | Online Article Text |
id | pubmed-9876977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98769772023-01-27 Expression and clinical significance of short-chain fatty acids in pregnancy complications Chen, Siqian Li, Jialin Ren, Shuaijun Gao, Yajie Zhou, Yuping Xuan, Rongrong Front Cell Infect Microbiol Cellular and Infection Microbiology OBJECTIVE: To investigate the expression of short-chain fatty acids (SCFAs)—metabolites of intestinal flora—in gestational complications of gestational diabetes mellitus (GDM), preeclampsia (PE), and intrahepatic cholestasis of pregnancy (ICP), and its clinical significance. METHODS: Targeted metabonomics was used to detect SCFAs in the serum of 28 GDM pregnant women, 28 PE pregnant women, 29 ICP pregnant women, and 27 healthy pregnant women (NP); their expression changes were observed; the correlation between SCFAs and clinical characteristics was studied; and their potential as biomarkers for clinical diagnosis was evaluated. RESULTS: There were significant differences in the SCFA metabolic spectrum between the GDM, PE, ICP, and NP groups. Quantitative analysis showed that the content of isobutyric acid in the three pregnancy complications groups (the GDM, PE, and ICP groups) was significantly higher than that in the NP group (p < 0.05), and other SCFAs also showed significant differences in the three pregnancy complications groups compared with the NP group (p < 0.05). Receiver operating characteristic (ROC) curve analysis of the generalized linear model showed that multiple SCFAs were highly sensitive and specific as diagnostic markers in the pregnancy complications groups, where isobutyric acid was highly predictive in GDM (area under the ROC curve (AUC) = 0.764) and PE (AUC = 1), and caproic acid was highly predictive in ICP (AUC = 0.968), with potential clinical application. CONCLUSION: The metabolic products of intestinal flora, SCFAs, during pregnancy are closely related to pregnancy complications (GDM, PE, and ICP), and SCFAs can be used as potential markers of pregnancy complications. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9876977/ /pubmed/36710961 http://dx.doi.org/10.3389/fcimb.2022.1071029 Text en Copyright © 2023 Chen, Li, Ren, Gao, Zhou and Xuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Chen, Siqian Li, Jialin Ren, Shuaijun Gao, Yajie Zhou, Yuping Xuan, Rongrong Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title | Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title_full | Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title_fullStr | Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title_full_unstemmed | Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title_short | Expression and clinical significance of short-chain fatty acids in pregnancy complications |
title_sort | expression and clinical significance of short-chain fatty acids in pregnancy complications |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876977/ https://www.ncbi.nlm.nih.gov/pubmed/36710961 http://dx.doi.org/10.3389/fcimb.2022.1071029 |
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