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Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection
This case–control study aimed to identify the clinical characteristics and explore the risk factors for liver fibrosis in metabolic associated fatty liver disease (MAFLD) patients with hepatitis B virus (HBV) infection. The patients were grouped into MAFLD + HBV and MAFLD (without HBV infection). Pr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877001/ https://www.ncbi.nlm.nih.gov/pubmed/36697471 http://dx.doi.org/10.1038/s41598-023-28351-3 |
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author | Lv, Haifeng Jiang, Yanming Zhu, Geli Liu, Shiyi Wang, Dian Wang, Jie Zhao, Ke Liu, Jing |
author_facet | Lv, Haifeng Jiang, Yanming Zhu, Geli Liu, Shiyi Wang, Dian Wang, Jie Zhao, Ke Liu, Jing |
author_sort | Lv, Haifeng |
collection | PubMed |
description | This case–control study aimed to identify the clinical characteristics and explore the risk factors for liver fibrosis in metabolic associated fatty liver disease (MAFLD) patients with hepatitis B virus (HBV) infection. The patients were grouped into MAFLD + HBV and MAFLD (without HBV infection). Propensity score matching (PSM) was used to match baseline features between the groups. We included 401 patients with biopsy-proven MAFLD, 179 of whom had HBV infection. A total of 83 pairs were successfully matched via PSM, and steatosis scores and ballooning in the MAFLD + HBV group were lower than those in the MAFLD group, while the inflammation scores and liver fibrosis stages were higher. After adjusted for confounding factors, HBV infection was associated with a higher risk of significant liver fibrosis in patients with MAFLD [odds ratio (OR): 3.140, P = 0.003]. Overall, 43.58% (78/179) of patients in the MAFLD + HBV group had significant liver fibrosis. Further multivariate regression analysis, hypertension (OR: 2.640; P = 0.031), type 2 diabetes (OR: 4.939; P = 0.035), and elevated glutamyl-transferase levels (OR: 3.980; P = 0.001) were risk factors for liver fibrosis in the MAFLD + HBV group. This suggests metabolic rather than viral factors are more closely associated with liver fibrosis in MAFLD patients with HBV infection. |
format | Online Article Text |
id | pubmed-9877001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98770012023-01-27 Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection Lv, Haifeng Jiang, Yanming Zhu, Geli Liu, Shiyi Wang, Dian Wang, Jie Zhao, Ke Liu, Jing Sci Rep Article This case–control study aimed to identify the clinical characteristics and explore the risk factors for liver fibrosis in metabolic associated fatty liver disease (MAFLD) patients with hepatitis B virus (HBV) infection. The patients were grouped into MAFLD + HBV and MAFLD (without HBV infection). Propensity score matching (PSM) was used to match baseline features between the groups. We included 401 patients with biopsy-proven MAFLD, 179 of whom had HBV infection. A total of 83 pairs were successfully matched via PSM, and steatosis scores and ballooning in the MAFLD + HBV group were lower than those in the MAFLD group, while the inflammation scores and liver fibrosis stages were higher. After adjusted for confounding factors, HBV infection was associated with a higher risk of significant liver fibrosis in patients with MAFLD [odds ratio (OR): 3.140, P = 0.003]. Overall, 43.58% (78/179) of patients in the MAFLD + HBV group had significant liver fibrosis. Further multivariate regression analysis, hypertension (OR: 2.640; P = 0.031), type 2 diabetes (OR: 4.939; P = 0.035), and elevated glutamyl-transferase levels (OR: 3.980; P = 0.001) were risk factors for liver fibrosis in the MAFLD + HBV group. This suggests metabolic rather than viral factors are more closely associated with liver fibrosis in MAFLD patients with HBV infection. Nature Publishing Group UK 2023-01-25 /pmc/articles/PMC9877001/ /pubmed/36697471 http://dx.doi.org/10.1038/s41598-023-28351-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lv, Haifeng Jiang, Yanming Zhu, Geli Liu, Shiyi Wang, Dian Wang, Jie Zhao, Ke Liu, Jing Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title | Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title_full | Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title_fullStr | Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title_full_unstemmed | Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title_short | Liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis B virus infection |
title_sort | liver fibrosis is closely related to metabolic factors in metabolic associated fatty liver disease with hepatitis b virus infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877001/ https://www.ncbi.nlm.nih.gov/pubmed/36697471 http://dx.doi.org/10.1038/s41598-023-28351-3 |
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