Cancer risk among HIV-exposed uninfected children in the United States

In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was bor...

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Detalles Bibliográficos
Autores principales: Horner, Marie-Josèphe, Hazra, Rohan, Barnholtz-Sloan, Jill S., Shiels, Meredith S., Engels, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877176/
https://www.ncbi.nlm.nih.gov/pubmed/36544264
http://dx.doi.org/10.1097/QAD.0000000000003458
Descripción
Sumario:In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.

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