Cancer risk among HIV-exposed uninfected children in the United States

In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was bor...

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Autores principales: Horner, Marie-Josèphe, Hazra, Rohan, Barnholtz-Sloan, Jill S., Shiels, Meredith S., Engels, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877176/
https://www.ncbi.nlm.nih.gov/pubmed/36544264
http://dx.doi.org/10.1097/QAD.0000000000003458
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author Horner, Marie-Josèphe
Hazra, Rohan
Barnholtz-Sloan, Jill S.
Shiels, Meredith S.
Engels, Eric A.
author_facet Horner, Marie-Josèphe
Hazra, Rohan
Barnholtz-Sloan, Jill S.
Shiels, Meredith S.
Engels, Eric A.
author_sort Horner, Marie-Josèphe
collection PubMed
description In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.
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spelling pubmed-98771762023-02-07 Cancer risk among HIV-exposed uninfected children in the United States Horner, Marie-Josèphe Hazra, Rohan Barnholtz-Sloan, Jill S. Shiels, Meredith S. Engels, Eric A. AIDS Research Letter In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers. Lippincott Williams & Wilkins 2023-03-01 2022-12-22 /pmc/articles/PMC9877176/ /pubmed/36544264 http://dx.doi.org/10.1097/QAD.0000000000003458 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Letter
Horner, Marie-Josèphe
Hazra, Rohan
Barnholtz-Sloan, Jill S.
Shiels, Meredith S.
Engels, Eric A.
Cancer risk among HIV-exposed uninfected children in the United States
title Cancer risk among HIV-exposed uninfected children in the United States
title_full Cancer risk among HIV-exposed uninfected children in the United States
title_fullStr Cancer risk among HIV-exposed uninfected children in the United States
title_full_unstemmed Cancer risk among HIV-exposed uninfected children in the United States
title_short Cancer risk among HIV-exposed uninfected children in the United States
title_sort cancer risk among hiv-exposed uninfected children in the united states
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877176/
https://www.ncbi.nlm.nih.gov/pubmed/36544264
http://dx.doi.org/10.1097/QAD.0000000000003458
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