Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits

Introduction: Genome editing by CRISPR-Cas9 approaches offers promise for introducing or correcting disease-associated mutations for research and clinical applications. Nonhuman primates are physiologically closer to humans than other laboratory animal models, providing ideal candidates for introduc...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, Jenna Kropp, Kim, Yun Hee, Strelchenko, Nick, Gierczic, Sarah R., Pavelec, Derek, Golos, Thaddeus G., Slukvin, Igor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genome Editing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877282/
https://www.ncbi.nlm.nih.gov/pubmed/36714391
http://dx.doi.org/10.3389/fgeed.2022.1031275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877282/
https://www.ncbi.nlm.nih.gov/pubmed/36714391
http://dx.doi.org/10.3389/fgeed.2022.1031275

Ejemplares similares