Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.

Three new hexadepsipeptides (1–3), along with beauvericin (4), beauvericin D (5), and four 4-hydroxy-2-pyridone derivatives (6–9) were isolated from the endophytic fungus Fusarium sp. CPCC 400857 that derived from the stem of tea plant. Their structures were determined by extensive 1D and 2D NMR, an...

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Autores principales: Chang, Shanshan, Yan, Biying, Chen, Yuchuan, Zhao, Wuli, Gao, Rongmei, Li, Yuhuan, Yu, Liyan, Xie, Yunying, Si, Shuyi, Chen, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877305/
https://www.ncbi.nlm.nih.gov/pubmed/36712984
http://dx.doi.org/10.3389/fchem.2022.1106869
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author Chang, Shanshan
Yan, Biying
Chen, Yuchuan
Zhao, Wuli
Gao, Rongmei
Li, Yuhuan
Yu, Liyan
Xie, Yunying
Si, Shuyi
Chen, Minghua
author_facet Chang, Shanshan
Yan, Biying
Chen, Yuchuan
Zhao, Wuli
Gao, Rongmei
Li, Yuhuan
Yu, Liyan
Xie, Yunying
Si, Shuyi
Chen, Minghua
author_sort Chang, Shanshan
collection PubMed
description Three new hexadepsipeptides (1–3), along with beauvericin (4), beauvericin D (5), and four 4-hydroxy-2-pyridone derivatives (6–9) were isolated from the endophytic fungus Fusarium sp. CPCC 400857 that derived from the stem of tea plant. Their structures were determined by extensive 1D and 2D NMR, and HRESIMS analyses. The absolute configuration of hexadepsipeptides were elucidated by the advanced Marfey’s method and chiral HPLC analysis. Compounds 4, and 7–9 displayed the cytotoxicity against human pancreatic cancer cell line, AsPC-1 with IC(50) values ranging from 3.45 to 29.69 μM, and 7 and 8 also showed the antiviral activity against the coronavirus (HCoV-OC43) with IC(50) values of 13.33 and 6.65 μM, respectively.
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spelling pubmed-98773052023-01-27 Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp. Chang, Shanshan Yan, Biying Chen, Yuchuan Zhao, Wuli Gao, Rongmei Li, Yuhuan Yu, Liyan Xie, Yunying Si, Shuyi Chen, Minghua Front Chem Chemistry Three new hexadepsipeptides (1–3), along with beauvericin (4), beauvericin D (5), and four 4-hydroxy-2-pyridone derivatives (6–9) were isolated from the endophytic fungus Fusarium sp. CPCC 400857 that derived from the stem of tea plant. Their structures were determined by extensive 1D and 2D NMR, and HRESIMS analyses. The absolute configuration of hexadepsipeptides were elucidated by the advanced Marfey’s method and chiral HPLC analysis. Compounds 4, and 7–9 displayed the cytotoxicity against human pancreatic cancer cell line, AsPC-1 with IC(50) values ranging from 3.45 to 29.69 μM, and 7 and 8 also showed the antiviral activity against the coronavirus (HCoV-OC43) with IC(50) values of 13.33 and 6.65 μM, respectively. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9877305/ /pubmed/36712984 http://dx.doi.org/10.3389/fchem.2022.1106869 Text en Copyright © 2023 Chang, Yan, Chen, Zhao, Gao, Li, Yu, Xie, Si and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chang, Shanshan
Yan, Biying
Chen, Yuchuan
Zhao, Wuli
Gao, Rongmei
Li, Yuhuan
Yu, Liyan
Xie, Yunying
Si, Shuyi
Chen, Minghua
Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title_full Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title_fullStr Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title_full_unstemmed Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title_short Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
title_sort cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic fusarium sp.
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877305/
https://www.ncbi.nlm.nih.gov/pubmed/36712984
http://dx.doi.org/10.3389/fchem.2022.1106869
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