The role of CD74 in cardiovascular disease

Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family p...

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Autores principales: Li, Qiu-Lin, Tang, Jing, Zhao, Ling, Ruze, Amanguli, Shan, Xue-Feng, Gao, Xiao-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877307/
https://www.ncbi.nlm.nih.gov/pubmed/36712241
http://dx.doi.org/10.3389/fcvm.2022.1049143
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author Li, Qiu-Lin
Tang, Jing
Zhao, Ling
Ruze, Amanguli
Shan, Xue-Feng
Gao, Xiao-Ming
author_facet Li, Qiu-Lin
Tang, Jing
Zhao, Ling
Ruze, Amanguli
Shan, Xue-Feng
Gao, Xiao-Ming
author_sort Li, Qiu-Lin
collection PubMed
description Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family proteins (MIF/MIF2). Many studies have revealed that CD74 plays an important role in cardiovascular disease. In this review, we summarize the structure and main functions of CD74 and then focus on the recent research progress on the role of CD74 in cardiovascular diseases. In addition, we also discuss potential treatment strategies that target CD74. Our systematic review of the role of CD74 in cardiovascular disease will fill some knowledge gaps in the field.
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spelling pubmed-98773072023-01-27 The role of CD74 in cardiovascular disease Li, Qiu-Lin Tang, Jing Zhao, Ling Ruze, Amanguli Shan, Xue-Feng Gao, Xiao-Ming Front Cardiovasc Med Cardiovascular Medicine Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family proteins (MIF/MIF2). Many studies have revealed that CD74 plays an important role in cardiovascular disease. In this review, we summarize the structure and main functions of CD74 and then focus on the recent research progress on the role of CD74 in cardiovascular diseases. In addition, we also discuss potential treatment strategies that target CD74. Our systematic review of the role of CD74 in cardiovascular disease will fill some knowledge gaps in the field. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9877307/ /pubmed/36712241 http://dx.doi.org/10.3389/fcvm.2022.1049143 Text en Copyright © 2023 Li, Tang, Zhao, Ruze, Shan and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Li, Qiu-Lin
Tang, Jing
Zhao, Ling
Ruze, Amanguli
Shan, Xue-Feng
Gao, Xiao-Ming
The role of CD74 in cardiovascular disease
title The role of CD74 in cardiovascular disease
title_full The role of CD74 in cardiovascular disease
title_fullStr The role of CD74 in cardiovascular disease
title_full_unstemmed The role of CD74 in cardiovascular disease
title_short The role of CD74 in cardiovascular disease
title_sort role of cd74 in cardiovascular disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877307/
https://www.ncbi.nlm.nih.gov/pubmed/36712241
http://dx.doi.org/10.3389/fcvm.2022.1049143
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