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Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism

Hematopoietic stem cell transplantation (HSCT) is an established therapeutic strategy for the treatment of malignant (leukemia and lymphoma) and non-malignant (thalassemia, anemia, and immunodeficiency) hematopoietic diseases. Thanks to the improvement in patient care and the development of more tol...

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Autores principales: Miglietta, Francesca, Iamartino, Luca, Palmini, Gaia, Giusti, Francesca, Marini, Francesca, Iantomasi, Teresa, Brandi, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877332/
https://www.ncbi.nlm.nih.gov/pubmed/36714597
http://dx.doi.org/10.3389/fendo.2022.1085315
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author Miglietta, Francesca
Iamartino, Luca
Palmini, Gaia
Giusti, Francesca
Marini, Francesca
Iantomasi, Teresa
Brandi, Maria Luisa
author_facet Miglietta, Francesca
Iamartino, Luca
Palmini, Gaia
Giusti, Francesca
Marini, Francesca
Iantomasi, Teresa
Brandi, Maria Luisa
author_sort Miglietta, Francesca
collection PubMed
description Hematopoietic stem cell transplantation (HSCT) is an established therapeutic strategy for the treatment of malignant (leukemia and lymphoma) and non-malignant (thalassemia, anemia, and immunodeficiency) hematopoietic diseases. Thanks to the improvement in patient care and the development of more tolerable conditioning treatments, which has extended the applicability of therapy to the elderly, a growing number of patients have successfully benefited from HSCT therapy and, more importantly, HSCT transplant-related mortality has consistently reduced in recent years. However, concomitantly to long term patient survival, a growing incidence of late HSCT-related sequelae has been reported, being variably associated with negative effects on quality of life of patients and having a non-negligible impact on healthcare systems. The most predominantly observed HSCT-caused complications are chronic alterations of the endocrine system and metabolism, which endanger post-operative quality of life and increase morbidity and mortality of transplanted patients. Here, we specifically review the current knowledge on HSCT-derived side-effects on the perturbation of mineral metabolism; in particular, the homeostasis of calcium, focusing on current reports regarding osteoporosis and recurrent renal dysfunctions that have been observed in a percentage of HSC-transplanted patients. Possible secondary implications of conditioning treatments for HSCT on the physiology of the parathyroid glands and calcium homeostasis, alone or in association with HSCT-caused renal and bone defects, are critically discussed as well.
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spelling pubmed-98773322023-01-27 Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism Miglietta, Francesca Iamartino, Luca Palmini, Gaia Giusti, Francesca Marini, Francesca Iantomasi, Teresa Brandi, Maria Luisa Front Endocrinol (Lausanne) Endocrinology Hematopoietic stem cell transplantation (HSCT) is an established therapeutic strategy for the treatment of malignant (leukemia and lymphoma) and non-malignant (thalassemia, anemia, and immunodeficiency) hematopoietic diseases. Thanks to the improvement in patient care and the development of more tolerable conditioning treatments, which has extended the applicability of therapy to the elderly, a growing number of patients have successfully benefited from HSCT therapy and, more importantly, HSCT transplant-related mortality has consistently reduced in recent years. However, concomitantly to long term patient survival, a growing incidence of late HSCT-related sequelae has been reported, being variably associated with negative effects on quality of life of patients and having a non-negligible impact on healthcare systems. The most predominantly observed HSCT-caused complications are chronic alterations of the endocrine system and metabolism, which endanger post-operative quality of life and increase morbidity and mortality of transplanted patients. Here, we specifically review the current knowledge on HSCT-derived side-effects on the perturbation of mineral metabolism; in particular, the homeostasis of calcium, focusing on current reports regarding osteoporosis and recurrent renal dysfunctions that have been observed in a percentage of HSC-transplanted patients. Possible secondary implications of conditioning treatments for HSCT on the physiology of the parathyroid glands and calcium homeostasis, alone or in association with HSCT-caused renal and bone defects, are critically discussed as well. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9877332/ /pubmed/36714597 http://dx.doi.org/10.3389/fendo.2022.1085315 Text en Copyright © 2023 Miglietta, Iamartino, Palmini, Giusti, Marini, Iantomasi and Brandi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Miglietta, Francesca
Iamartino, Luca
Palmini, Gaia
Giusti, Francesca
Marini, Francesca
Iantomasi, Teresa
Brandi, Maria Luisa
Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title_full Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title_fullStr Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title_full_unstemmed Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title_short Endocrine sequelae of hematopoietic stem cell transplantation: Effects on mineral homeostasis and bone metabolism
title_sort endocrine sequelae of hematopoietic stem cell transplantation: effects on mineral homeostasis and bone metabolism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877332/
https://www.ncbi.nlm.nih.gov/pubmed/36714597
http://dx.doi.org/10.3389/fendo.2022.1085315
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