Cargando…

Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease

The incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a m...

Descripción completa

Detalles Bibliográficos
Autor principal: Larsen, Olaf F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877340/
https://www.ncbi.nlm.nih.gov/pubmed/36712507
http://dx.doi.org/10.3389/fnut.2022.1107016
_version_ 1784878346010624000
author Larsen, Olaf F. A.
author_facet Larsen, Olaf F. A.
author_sort Larsen, Olaf F. A.
collection PubMed
description The incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a modality for both prevention and treatment/adjuvant therapy. At very young age, nutritional intervention targeting the gut microbiota is still possible within a one-size-fits all regime, accompanied by a relatively high effect size. As ageing results in higher interindividual variation induced by cumulative exposome factors, a more personalized approach is needed, having a higher effect size than that of current nutritional intervention. As such, supplementation of microbial consortia consisting of keystone taxa and microbial guilds that are involved in the pathophysiology seem a promising direction to lower the burden of autoimmune disease.
format Online
Article
Text
id pubmed-9877340
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98773402023-01-27 Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease Larsen, Olaf F. A. Front Nutr Nutrition The incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a modality for both prevention and treatment/adjuvant therapy. At very young age, nutritional intervention targeting the gut microbiota is still possible within a one-size-fits all regime, accompanied by a relatively high effect size. As ageing results in higher interindividual variation induced by cumulative exposome factors, a more personalized approach is needed, having a higher effect size than that of current nutritional intervention. As such, supplementation of microbial consortia consisting of keystone taxa and microbial guilds that are involved in the pathophysiology seem a promising direction to lower the burden of autoimmune disease. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9877340/ /pubmed/36712507 http://dx.doi.org/10.3389/fnut.2022.1107016 Text en Copyright © 2023 Larsen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Larsen, Olaf F. A.
Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title_full Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title_fullStr Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title_full_unstemmed Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title_short Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
title_sort nurturing by nutrition: on the future of gut microbiota management strategies for autoimmune disease
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877340/
https://www.ncbi.nlm.nih.gov/pubmed/36712507
http://dx.doi.org/10.3389/fnut.2022.1107016
work_keys_str_mv AT larsenolaffa nurturingbynutritiononthefutureofgutmicrobiotamanagementstrategiesforautoimmunedisease