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DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method

Resilience is a process associated with the ability to recover from stress and adversity. We aimed to explore the resilience-associated DNA methylation signatures and evaluate the abilities of methylation risk scores to discriminate low resilience (LR) individuals. The study recruited 78 young adult...

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Autores principales: Lu, Andrew Ke-Ming, Hsieh, Shulan, Yang, Cheng-Ta, Wang, Xin-Yu, Lin, Sheng-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877348/
https://www.ncbi.nlm.nih.gov/pubmed/36712885
http://dx.doi.org/10.3389/fgene.2022.1046700
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author Lu, Andrew Ke-Ming
Hsieh, Shulan
Yang, Cheng-Ta
Wang, Xin-Yu
Lin, Sheng-Hsiang
author_facet Lu, Andrew Ke-Ming
Hsieh, Shulan
Yang, Cheng-Ta
Wang, Xin-Yu
Lin, Sheng-Hsiang
author_sort Lu, Andrew Ke-Ming
collection PubMed
description Resilience is a process associated with the ability to recover from stress and adversity. We aimed to explore the resilience-associated DNA methylation signatures and evaluate the abilities of methylation risk scores to discriminate low resilience (LR) individuals. The study recruited 78 young adults and used Connor-Davidson Resilience Scale (CD-RISC) to divide them into low and high resilience groups. We randomly allocated all participants of two groups to the discovery and validation sets. We used the blood DNA of the subjects to conduct a genome-wide methylation scan and identify the significant methylation differences of CpG Sites in the discovery set. Moreover, the classification accuracy of the DNA methylation probes was confirmed in the validation set by real-time quantitative methylation-specific polymerase chain reaction. In the genome-wide methylation profiling between LR and HR individuals, seventeen significantly differentially methylated probes were detected. In the validation set, nine DNA methylation signatures within gene coding regions were selected for verification. Finally, three methylation probes [cg18565204 (AARS), cg17682313 (FBXW7), and cg07167608 (LINC01107)] were included in the final model of the methylation risk score for LR versus HR. These methylation risk score models of low resilience demonstrated satisfactory discrimination by logistic regression and support vector machine, with an AUC of 0.81 and 0.93, accuracy of 72.3% and 87.1%, sensitivity of 75%, and 87.5%, and specificity of 70% and 80%. Our findings suggest that methylation signatures can be utilized to identify individuals with LR and establish risk score models that may contribute to the field of psychology.
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spelling pubmed-98773482023-01-27 DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method Lu, Andrew Ke-Ming Hsieh, Shulan Yang, Cheng-Ta Wang, Xin-Yu Lin, Sheng-Hsiang Front Genet Genetics Resilience is a process associated with the ability to recover from stress and adversity. We aimed to explore the resilience-associated DNA methylation signatures and evaluate the abilities of methylation risk scores to discriminate low resilience (LR) individuals. The study recruited 78 young adults and used Connor-Davidson Resilience Scale (CD-RISC) to divide them into low and high resilience groups. We randomly allocated all participants of two groups to the discovery and validation sets. We used the blood DNA of the subjects to conduct a genome-wide methylation scan and identify the significant methylation differences of CpG Sites in the discovery set. Moreover, the classification accuracy of the DNA methylation probes was confirmed in the validation set by real-time quantitative methylation-specific polymerase chain reaction. In the genome-wide methylation profiling between LR and HR individuals, seventeen significantly differentially methylated probes were detected. In the validation set, nine DNA methylation signatures within gene coding regions were selected for verification. Finally, three methylation probes [cg18565204 (AARS), cg17682313 (FBXW7), and cg07167608 (LINC01107)] were included in the final model of the methylation risk score for LR versus HR. These methylation risk score models of low resilience demonstrated satisfactory discrimination by logistic regression and support vector machine, with an AUC of 0.81 and 0.93, accuracy of 72.3% and 87.1%, sensitivity of 75%, and 87.5%, and specificity of 70% and 80%. Our findings suggest that methylation signatures can be utilized to identify individuals with LR and establish risk score models that may contribute to the field of psychology. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9877348/ /pubmed/36712885 http://dx.doi.org/10.3389/fgene.2022.1046700 Text en Copyright © 2023 Lu, Hsieh, Yang, Wang and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Lu, Andrew Ke-Ming
Hsieh, Shulan
Yang, Cheng-Ta
Wang, Xin-Yu
Lin, Sheng-Hsiang
DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title_full DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title_fullStr DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title_full_unstemmed DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title_short DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method
title_sort dna methylation signature of psychological resilience in young adults: constructing a methylation risk score using a machine learning method
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877348/
https://www.ncbi.nlm.nih.gov/pubmed/36712885
http://dx.doi.org/10.3389/fgene.2022.1046700
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