Filtered Cerebrospinal Fluid From Patients With Amyotrophic Lateral Sclerosis Displays an Altered Proteome and Affects Motor Phenotype in a Mouse Model

Introduction: Cerebrospinal fluid (CSF) has been implicated in amyotrophic lateral sclerosis (ALS) due to its ability to spread inflammatory proteins throughout the nervous system. We hypothesized that filtration of the CSF could remove pathogenic proteins and prevent them from altering motor phenot...

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Detalles Bibliográficos
Autores principales: Venkatraman, Vishal, Filiano, Anthony J, Xu, Li, Collins, Leonard, Luo, Emily, Ripple, Katelyn M, de Castro, George C, Boua, Jane-Valeriane K, Marius, Choiselle, Giamberardino, Charles, Lad, Shivanand P, Islam Williams, Taufika, Bereman, Michael S, Bedlack, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877488/
https://www.ncbi.nlm.nih.gov/pubmed/36712738
http://dx.doi.org/10.7759/cureus.32980

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