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Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors

Plasmodium falciparum (Pf) 5-aminolevulinic acid synthase (5-ALAS) is an essential enzyme with high selectivity during liver stage development, signifying its potential as a prophylactic antimalarial drug target. The aim of this study was to identify important potential lead compounds which can serv...

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Detalles Bibliográficos
Autores principales:	Oduselu, Gbolahan O., Afolabi, Rufus, Ademuwagun, Ibitayo, Vaughan, Ashley, Adebiyi, Ezekiel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877529/ https://www.ncbi.nlm.nih.gov/pubmed/36714108 http://dx.doi.org/10.3389/fmed.2022.1022429

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